不同年龄肠道菌群的变化和阿尔茨海默病的关系

Relationship between changes of gut microbiota at different ages and Alzheimer's disease

阿尔茨海默病(Alzheimer’s disease,AD)是一种以进行性认知障碍为临床表现的神经退行性疾病,具体发病机制尚不明确。肠道菌群失调与AD的发生密切相关,在AD的发生发展中发挥重要作用。肠道菌群可以通过神经、内分泌和免疫等通道与中枢神经系统进行交流,并且可能通过产生有害物质、分泌或调节神经递质以及诱导神经炎症等方式引起神经退行性病变。本文通过总结肠道菌群在各年龄段与认知的关系,分析肠道菌群影响AD的可能机制,以期为AD的防治提供新的研究方向。

Alzheimer's disease is a neurodegenerative disease with progressive cognitive impairment as its clinical manifestation,and the specific pathogenesis is still unclear Gut microbiota imbalance is closely related to the occurrence of AD and plays an important role in the occurrence and development of AD.Gut microbiota can communicate with the central nervous system through neural,endocrine and immune channels,and may cause neurodegenerative diseases by producing harmful substances,secreting or regulating neurotransmitters,inducing neuroinflammation.This paper aims to provide a new research directions for the prevention and treatment of AD by summarizing the relationship between intestinal flora and cognition at different ages and analyzing the correlation between gut microbiota and the pathogenesis of AD.