基于方证相应的肝郁脾虚证生物学基础述评

Commentary on biological mechanism of liver qi depression and spleen deficiency syndrome based on the correlation of prescription and syndrome

肝郁脾虚证是以肝失疏泄、脾失健运为病机,以胁胀作痛、情志抑郁、腹胀便溏为主症的证候,多见于肝病、胃痛、肠易激综合征、抑郁症等疾病,是现代临床常见证候。证本质的研究是中医辨证研究的关键,也是指导疾病治疗的基础。文章在总结课题组及领域内相关研究的基础上,以方证相应为指导,以“药效机制-证候本质”为耦合,揭示了神经-内分泌-免疫网络紊乱与神经-消化-循环系统失衡作为“肝郁”与“脾虚”证候病机生物学基础的核心、阐明了肠道微生物-免疫系统-脑轴失衡是介导肝郁脾虚证病机演变转化的关键机制。

liver qi depression and spleen deficiency syndrome is a common pattern in modern clinic with symptoms of hypochondrium distending pain,depression of emotion,abdominal distension and loose stool and so on.It is mostly shown in liver disease,stomach pain,depression and other diseases,with the pathogenesis of liver dysfunction and dysfunction of spleen in transport.As we all know,identifying the core of syndromes is the key to differentiate syndromes and established the base for therapy.Guiding by the theory of correlating prescription and syndrome,we have summarized research results of our group and others in this field and deeply explored the biological mechanism of liver qi depression and spleen deficiency syndrome.Linking them with biological mechanism and the core of syndromes,we revealed the core of liver qi depression and spleen deficiency syndrome is the disorder of neuro-immuno-endocrine network and the imbalance of neuro-digestive-circulatory system,and the key mechanism of converting is the imbalance of intestinal Microbiome-immuno-brain axis may play an important role.