运气方对高海拔地区慢性萎缩性胃炎患者病理征象的影响

Effect of Yunqi Fang on Pathological Signs of Patients with Chronic Atrophic Gastritis in High-altitude Areas of Qinghai

目的:探讨运气方对不同高海拔地区慢性萎缩性胃炎患者病理征象的影响。方法:选取2020年11月—2022年2月青海省中医院脾胃病科门诊和住院部、龙砂特色门诊(海拔2 200 m)及海西蒙古族藏族自治州德令哈市中医院(海拔3 080 m)、果洛藏族自治州玛沁县人民医院(海拔4 100 m)各60例幽门螺杆菌(Hp)阳性的慢性萎缩性胃炎患者,共180例,随机分为对照组2 000m、对照组3 000 m、对照组4 000 m、观察组2 000 m、观察组3 000 m、观察组4 000 m各30例。对照组予以西医标准四联疗法,观察组予以西医标准四联用药+运气方治疗,两组均治疗4周,观察并比较不同海拔地区治疗前后病理征象积分,并进行病理组织学疗效评价。结果:(1)治疗后,相同海拔地区两组病理征象积分较治疗前有所下降,除对照组3 000 m外,余组比较,差异均有统计学意义(P<0.05);(2)慢性炎症病理征象改善方面,3个不同海拔地区组间治疗后与治疗前比较,差异均有统计学意义(P<0.05)。萎缩、肠化、病理异常增生征象改善方面,3个不同海拔地区组间比较,差异均无统计学意义(P> 0.05);(3)3个不同海拔地区总有效率比较,差异有统计学意义(P<0.05)。结论:(1)不同海拔地区海拔间征象积分、单个病理征象评分存在明显差异;(2)运气方能够改善胃组织病理征象状态。

Objective:The target of this study is to observe the effect of Yunqi fang on the pathological signs of chronic atrophic gastritis patients in different high altitude areas of Qinghai.Methods:With the consent of the Medical Ethics Committee of Traditional Chinese Medicine Hospital of Qinghai,60 cases of H.pylori.were selected from the outpatient and inpatient departments of the Spleen and Stomach Disease Department of Qinghai Provincial Hospital of Traditional Chinese Medicine from November 2020 to February 2022,as well as the Longsha Characteristic Outpatient Department(at an altitude of 2200 meters),Delingha Traditional Chinese Medicine Hospital(at an altitude of 3080 meters),and Maqin County People's Hospital(at an altitude of 4100 meters).A total of 180 patients with chronic atrophic gastritis were diagnosed as positive for Pylori.Stratified randomization was conducted at the same altitude,and they were randomly divided into a control group of 2 000m,a control group of 3000 m,a control group of 4000 m,an observation group of 2000 m,an observation group of 3000 m,and an observation group of 3000 m.The control group was treated with Western medicine standard quadruple therapy,while the observation group was treated with Western medicine standard quadruple therapy+Yunqi fang.Both groups were treated for 4 weeks,and the histopathological scores before and after treatment at three altitudes were compared,and the therapeutic effects of histopathology were evaluated.Results:l.After treatment,compared with the control group and the observation group at the same altitude,the pathological sign scores of the two groups decreased,and there was a statistically significant difference in the improvement of individual pathological signs of chronic inflammation and atrophy(P<0.05).2.In terms of improving the pathological signs of chronic inflammation,there were statistically significant differences between the three groups at different altitudes after treatment and before treatment(P<0.05).There was no statistically significant difference in the improvement of signs of atrophy,intestinal metaplasia,and pathological dysplasia among the three groups at different altitudes(P>0.05).3.There was a statistically significant difference in the total effective rate among three different altitude regions(P<0.05).Conclusion:1.There are significant differences in histopathological scores and individual pathological tissue sign scores between different altitudes in different regions;2.Yunqi fang can improve the pathological signs of gastric tissue.