布鲁氏菌性脊柱炎动物模型研究进展

Research progress on animal model of Brucella spondylitis

布鲁氏菌病是由布鲁氏菌引起的一种人畜共患传染病。布鲁氏菌集中于脊柱局部侵蚀椎体等组织引发腰背疼痛等相关症状,即为布鲁氏菌性脊柱炎。近年来,布鲁氏菌性脊柱炎发病率增高,临床中漏诊和误诊也时有发生。布鲁氏菌性脊柱炎发病机制较为复杂,目前尚无定论,故临床前实验显得尤为重要,动物模型是基础研究的重要方式,合适的模型研究对临床医生治疗疾病有指导意义。布鲁氏菌性脊柱炎较为复杂,动物模型建立相对困难。作者通过对已建立的动物模型进行分析讨论,以期为后续动物造模研究提供参考。

Brucellosis is a zoonotic disease caused by Brucella.Brucella concentrated in the local erosion of spine vertebrae and other tissues causes low back pain and other related symptoms,that is,Brucella spondylitis(BS).In recent years,the incidence of BS increased,and missed diagnosis and misdiagnosis occurred from time to time.The pathogenesis of BS is complex,and it has not been accurately identified at present,so the preclinical experiment is particularly important.Animal model is an important way of basic research,and appropriate model research could provide guidance to clinicians for disease treatment.BS is rather complex,and the establishment of animal model is relatively difficult.In this paper,the established animal models are analyzed and discussed in order to provide reference for subsequent animal model research.