补中益气汤联合倍他司汀治疗气虚血瘀型良性阵发性位置性眩晕复位后残余症状的临床观察

Clinical observation on the effect of a combined therapy with Buzhong Yiqi Decoction and betahistine on the residual symptoms of patients with BPPV in the pattern of Qi deficiency and blood stasis following canalith repositioning maneuvers

目的观察补中益气汤联合倍他司汀治疗良性阵发性位置性眩晕(BPPV)复位后残余症状的有效性和安全性。方法2020年6月~2021年6月我院收治的原发性BPPV复位成功后伴残余症状的气虚血瘀型患者160例,随机分为观察组和对照组,每组80例。两组患者均口服甲磺酸倍他司汀治疗,观察组患者联合应用补中益气汤,疗程2周;自治疗开始随访2个月。比较两组患者治疗前后眩晕障碍量表(DHI)评分、临床疗效以及不良反应发生情况以及残余症状持续时间。结果治疗结束后,两组患者DHI评分均较治疗前显著降低(P<0.05),但观察组治疗后DHI评分低于对照组,差异有统计学意义(P<0.05);观察组总有效率95.00%,显著高于对照组的78.75%(P<0.05);观察组和对照组患者残余症状持续时间分别为13(9~23)d和17(10~29)d,观察组患者残余症状持续时间显著低于对照组(P<0.05);治疗过程中,两组患者均未发生不良反应。结论补中益气汤联合倍他司汀能快速、有效地缓解气虚血瘀型BPPV患者复位后残余症状,安全性良好,值得临床推广。

Objective To investigate the efficacy and safety of the therapy combined Buzhong Yiqi Decoction(BZYQD)with betahistine on the residual symptoms of patients with benign paroxysmal positional vertigo(BPPV)in the pattern of Qi deficiency and blood stasis(QDBS)following canalith repositioning maneuvers.Methods Included in this trial were 160 BPPV patients with residual symptoms in the pattern of Qi deficiency and blood stasis following canalith repositioning maneuvers,treated in our hospital from Jun.2020 to Jun.2021.They were randomly divided into observation group(OG)and control group(CG),with 80 cases in each.The cases in both groups were all given betahistine similarly during the treating period,but BZYQD being given additionally to the cases only in OG,with the therapy lasted for two weeks for these two groups.Then,all the cases in both groups were followed up for 2 months.By the end of the following up period,comparatively analyzed between the two groups were the such residual symptoms as dizziness handicap inventory(DHI)score,clinical efficacy,and the incidence of side effects.Results As observed by the end of therapy,DHI scores were obviously decreased in all the cases in both groups(P<0.05),but with the scores significantly lower in OG than that in CG(P<0.05).The total effective rate of OG was 93.48%,significantly higher than the rate of 72.92%in CG(P<0.05).The lasting durations of residual symptoms were 13(9~23)d in OG and 17(10~29)d in CG respectively,with obviously statistical significance between them(P<0.05).There were no any side effects observed among all these cases in both groups during the treating period.Conclusions It may be concluded based on this trial that the combined therapy with BZYQD and betahistine can quickly and effectively relieve the residual symptoms following canalith repositioning maneuvers for cases with BPPV with very good safety.It is worthy of clinical promotion.