小檗碱抗真菌药理作用及其机制的研究进展

Research Progress in Antifungal Pharmacological Effects and Mechanism of Berberine

小檗碱在临床上主要被用于肠道感染,而广谱抗细菌作用是其发挥功效的药理基础。然而,小檗碱还具有很强的抗真菌作用,包括各种皮肤癣菌、假丝酵母属(Candida)、新生隐球酵母(Cryptococcus neoformans)、糠秕孢子菌(Pityrosporum orbiculare)、烟曲霉真菌(Aspergillus fumigatus)和马尔尼菲篮状菌(Talaromyces marneffei)等。本文主要就小檗碱对各种真菌的药理作用及其机制进行了综述,为小檗碱的临床开发提供参考。

Berberine is mainly used clinically for intestinal infection,and its broad-spectrum antibacterial effect is the pharmacological basis for exerting its functions.However,berberine also has strong antifungal effects against various dermatophytes,such as Candida,Cryptococcus neoformans,Pityrosporum orbiculare,Aspergillus fumigates,Talaromyces marneffei,etc.This article summarizes the pharmacological effects and mechanism of berberine against various fungi,and provides reference for the clinical development of berberine.