类风湿关节炎骨破坏的细胞网络调控及治疗研究进展

Advances in regulation of cellular network and treatment of bone destruction in rheumatoid arthritis

类风湿关节炎是一种累及多个关节的慢性全身性自身免疫性疾病,可引起不可逆转的关节畸形甚至残疾。骨破坏是类风湿关节炎患者关节损伤的主要原因,各细胞参与了骨破坏进程,相互作用形成复杂的网络。因此,该文综述了近年类风湿关节炎骨破坏中的细胞网络调控作用机制及药物治疗进展,拟阐明细胞网络调节类风湿关节炎骨破坏的过程,为开发类风湿关节炎骨破坏的防治药物提供思路。

Rheumatoid arthritis(RA)is a chronic autoimmune disease involving multiple joints and can cause irreversible joint deformity and even disability.Bone destruction is the primary cause of joint damage in RA patients,and various cells are involved in the process of bone destruction,interacting to form a complex network.Therefore,this review summarizes the mechanisms of regulation of cellular networks in the destruction of RA bones and the progress of pharmacotherapy in recent years,and elucidates the process of cell network regulation of RA bone destruction,so as to provide ideas for drug development for the prevention and treatment of RA bone destruction.