母乳喂养联合肠外营养支持对先天性巨结肠患者的疗效研究

Effect of Breast Feeding Combined with Parenteral Nutrition Support on Patients with Congenital Megacolon

目的:探讨母乳喂养联合肠外营养支持对先天性巨结肠患者的疗效。方法:选取2016年1月—2022年1月在广州市妇女儿童医疗中心接受治疗的60例先天性巨结肠患儿为研究对象,随机分为干预组、对照组,每组30例。对照组予以母乳喂养,干预组予以母乳喂养联合肠外营养制剂治疗,比较两组患儿体格发育指标、免疫功能、血清学指标水平、神经行为功能评分、不良反应发生率等。结果:治疗12周后,干预组体重、身高、头围均高于对照组(P<0.05)。随访3个月,干预组IgA、IgG、IgM水平高于对照组(P<0.05);干预组CaM、CGRP、Cx43水平低于对照组(P<0.05);干预组NBNA各项评分均高于对照组(P<0.05)。干预组、对照组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:母乳喂养联合肠外营养支持治疗先天性巨结肠患儿的效果显著,能够促进新生儿的体格发育,增加新生儿机体免疫力,改善新生儿的神经行为功能和脑神经功能,抑制血清学炎症因子指标的表达,治疗安全性良好,可临床推荐。

Objective:To investigate the effect of breast feeding combined with parenteral nutrition support on patients with congenital megacolon.Methods:Sixty children with congenital megacolon who were treated in Guangzhou Women and Children Medical Center from January 2016 to January 2022 were randomly divided into intervention group and control group,with 30 cases in each group.The control group was given breast feeding,and the intervention group was given breast feeding combined with parenteral nutrition preparation.The physical development index,immune function,serological index level,neurobehavioral function score,and incidence of adverse reactions between the two groups were compared.Results:After 12 weeks of treatment,the weight,height and head circumference of the intervention group were higher than those of the control group(P<0.05).Followup for 3 months,the levels of IgA,IgG and IgM in the intervention group were higher than those in the control group(P<0.05).The levels of CaM,CGRP and Cx43 in the intervention group were lower than those in the control group(P<0.05).The scores of NBNA in the intervention group were higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the intervention group and the control group(P>0.05).Conclusion:Breast feeding combined with parenteral nutrition support has remarkable effect in the treatment of children with congenital megacolon.It can promote the physical development of newborns,increase the immunity of newborns,improve the neurobehavioral function and brain function of newborns,and inhibit the expression of serological inflammatory factors.The treatment is safe and can be clinically recommended.