阿昔洛韦联合重组人干扰素α2b治疗IM患儿的效果研究

Effect of Acyclovir Combined with Recombinant Human Interferonα2b in the Treatment of Children with IM

目的:探讨阿昔洛韦联合重组人干扰素α2b治疗传染性单核细胞增多症(Infectious mononucleosis,IM)患儿的疗效及对肝功能、外周血细胞水平的影响。方法:选取2018年8月—2021年8月我院收治的60例IM患儿作为研究对象,随机分成对照组30例和观察组30例。对照组给予常规治疗手段以及阿昔洛韦静脉滴注,观察组在对照组基础上联合重组人干扰素α2b雾化吸入治疗。比较两组患儿临床症状改善时间、肝功能指标水平、外周血细胞水平恢复时间、心肌损伤指标水平以及不良反应情况。结果:观察组体温恢复、咽峡炎消失、肝大消失、脾大消失、颈部淋巴结肿大消失,WBC和异常淋巴细胞水平恢复时间均短于对照组(P<0.05);观察组谷丙转氨酶(ALT)、谷草转氨酶(GOT)、乳酸脱氢酶(LDH)和肌酸激酶同工酶(CK-MB)水平均低于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:重组人干扰素α2b联合阿昔洛韦治疗能缓解IM患儿的临床症状,减轻肝功能损伤,促进外周血细胞水平恢复,减轻心肌损伤,相比常规治疗效果较为显著。

Objective:To investigate the efficacy of acyclovir combined with recombinant human interferon α2b in the treatment of children with infectious mononucleosis(IM)and its influence on liver function and peripheral blood cell level.Methods:A total of 60 children with IM admitted to our hospital from August 2018 to August 2021 were randomly divided into control group(30 cases)and observation group(30 cases).The control group was given conventional treatment and intravenous drip of acyclovir,and the observation group was treated with aerosol inhalation of recombinant human interferon α2b on the basis of the control group.The improvement time of clinical symptoms,liver function index level,recovery time of peripheral blood cell level,myocardial injury index level and adverse reactions were compared between the two groups.Results:The recovery time of body temperature,angina,hepatomegaly,splenomegaly and cervical lymph node enlargement in the observation group was shorter than that in the control group(P<0.05).The levels of alanine aminotransferase(ALT),aspartate aminotransferase(GOT),lactate dehydrogenase(LDH)and creatine kinase isoenzyme(CK-MB)in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Recombinant human interferon α2b combined with acyclovir can relieve the clinical symptoms of children with IM,reduce liver function damage,promote the recovery of peripheral blood cell levels,and reduce myocardial damage,which is more effective than conventional treatment.