多元叠加整合声治疗主观性耳鸣疗效的影响因素分析

Influential factors of the efficacy of tinnitus multivariate integrated sound therapy for the treatment of subjective tinnitus

目的探讨多元叠加整合声治疗主观性耳鸣疗效的影响因素。方法选择2019年6月至2020年6月厦门大学附属第一医院收治的主观性耳鸣患者431例为研究对象,采用横断面研究方法,采用多元叠加整合声治疗(T-MIST)验配平台对耳鸣患者进行精细化检测,并采用耳鸣残疾量表评估耳鸣患者的严重程度,结合患者的基本特征,采用SPSS软件分析影响主观性耳鸣患者多元叠加整合声治疗效果的因素。结果多因素logistic回归分析结果显示,相对于短期耳鸣患者,病程为3~12个月的患者OR(95%CI)=1.982(1.033~3.804),P=0.040;病程为>12个月的患者OR(95%CI)=2.411(1.322~4.396),P=0.004;随着耳鸣残疾量表(THI)评分的增高,T-MIST的治疗效果越好[OR(95%CI)=1.014(1.004~1.024),P=0.007];听力补偿有效组的T-MIST治疗效果更好[OR(95%CI)=0.133(0.081~0.216),P<0.001]。结论病程长短、THI水平、听力补偿有效为多元叠加整合声治疗效果的影响因素,可为主观性耳鸣患者治疗提供依据。

Objective To investigate the influential factors of the efficacy of tinnitus multivariate integrated sound therapy(T-MIST)in the treatment of subjective tinnitus.Methods A total of 431 patients with subjective tinnitus who received treatment in The First Affiliated Hospital of Xiamen University from June 2019 to June 2020 were included in this study.A cross-sectional study method was used to conduct refined testing on tinnitus patients using the T-MIST matching platform.The severity of tinnitus patients was evaluated using the Tinnitus handicap inventory scale.SPSS software was used to analyze the factors affecting the effectiveness of the T-MIST for subjective tinnitus based on patients'basic characteristics.Results Multivariate logistic regression analysis showed that compared with patients with short-term tinnitus,OR(95%CI)was 1.982(1.033-3.804),P=0.040,in patients with 3-12 months of disease duration,OR(95%CI)was 2.411(1.322-4.396),P=0.004 in patients with>12 months of disease duration.With the increase in tinnitus handicap inventory score,the efficacy of T-MIST became better[OR(95%CI)=1.014(1.004-1.024),P=0.007].The efficacy of T-MIST was better in the hearing compensation-effective patients[OR(95%CI)=0.133(0.081-0.216),P<0.001].Conclusion The course of the disease,tinnitus handicap inventory score,and effective hearing compensation are the influential factors of T-MIST.They can provide evidence for the treatment of subjective tinnitus.