摘要
动脉粥样硬化斑块破裂是导致急性心肌梗死的重要诱因,严重威胁患者的生命安全。血管内动脉粥样硬化斑块的形成不仅仅与机体脂质代谢异常有关,还与免疫系统异常活化以及炎症因子与血管细胞之间的相互作用密切相关。多项研究表明,机体内多种免疫细胞在动脉粥样硬化过程中扮演着重要角色,提示动脉粥样硬化很可能属于炎症诱发的慢性血管疾病。综述了免疫细胞在动脉粥样硬化进程中作用的研究进展,并对相关免疫治疗策略进行简介,旨在为动脉粥样硬化的机制阐明与临床治疗提供思路与参考。
Rupture of atherosclerotic plaques in arterial blood vessels is a major trigger of acute myocardial infarction,which poses a serious threat to the patient's life.The formation of atherosclerotic plaques in blood vessels is not only associated with abnormal lipid metabolism in the body,but also closely related to abnormal activation of the immune system and the interaction between inflammatory factors and vascular cells.Several studies have shown that various immune cells in the body play important roles in the process of atherosclerosis,suggesting that atherosclerosis is likely to be a chronic vascular disease induced by inflammation.This article reviews the advances in research on the role of immune cells in the progression of atherosclerosis,and introduces the relevant immunotherapies,aiming to provide ideas and references for mechanisms elucidation and clinical treatment of atherosclerosis.
作者
李婧玉
李琦
陈畅
LI Jingyu;LI Qi;CHEN Chang(Department of Pharmacology,College of Pharmacy,Harbin Medical University,Harbin 150086,China;The Biotherapy Center,Harbin Medical University Cancer Hospital,Harbin 150086,China)
出处
《药学进展》
CAS
2023年第7期542-550,共9页
Progress in Pharmaceutical Sciences
基金
国家自然科学基金(No.81970382)。
