硒和硒蛋白与宿主肠道健康的互作调节机制

Role of selenium and selenoprotein in gut health

硒是生物体必需的微量元素之一,在体内合成为硒蛋白,参与抗氧化和免疫应答等众多生理机能的调控.近期研究表明,硒和硒蛋白可能与宿主肠道微生物、抗氧化系统和免疫因子存在互作调节肠道稳态的功能,进而起到预防和治疗肠道疾病的作用.本文综述了硒在肠道中的吸收和硒蛋白的合成及功能,重点解析了硒和硒蛋白与肠道微生物、肠道氧化应激和肠道免疫间的互作调节机制及其在肠癌中的潜在作用,以期为硒用于预防或治疗肠道疾病提供新的思路和依据.

Selenium,one of the essential trace elements for living organisms,participates in the regulation of physiological functions such as anti-oxidation and immune response when converted into selenoproteins.Recent studies have shown that selenium and selenoproteins may interact with host intestinal microbiota,antioxidant system,and immune factors to regulate intestinal homeostasis,therefore played a crucial role in the prevention and treatment of intestinal diseases.In this review,the absorption of selenium in the intestinal tract and the synthesis and function of selenoproteins were briefly introduced,the interactive regulation mechanism of selenium and selenoproteins with intestinal microbiota,intestinal oxidative stress,and intestinal immunity were discussed,and the potential role of selenium in intestinal cancer were analyzed,which provided new ideas and basis for the use of selenium in the prevention or treatment of intestinal diseases.