生物遗传与家庭环境因素在边缘型人格障碍发病机制中的研究进展

Research Progress of Genetic and Family Environmental Factors in the Pathogenesis of Borderline Personality Disorder

边缘型人格障碍(borderline personality disorder,BPD)是一种发病率与死亡率均较高的精神疾病,每年在全球范围内都会对公共心理卫生资源造成严重的负担。但目前其发生机制仍未有定论,许多研究也正处于起步阶段。遗传因素、环境因素以及神经生物因素在其发病过程中均起作用。家庭作为儿童青少年成长过程中的重要外部环境,对个体的人格形成以及身心健康起着不可替代的影响作用。本文从生物遗传、家庭环境以及基因-环境的相互作用三个角度对BPD的发生机制进行阐述,并总结了当前相关研究领域所面临的一些不足和挑战,希望为进一步的研究提供新思路,同时也为临床治疗和早期干预提供参考。

Borderline personality disorder(BPD)is a mental disorder with high morbidity and mortality,which poses a serious burden on public mental health resources worldwide every year.However,the mechanism of its occurrence is still uncertain,and many studies are still in their infancy.Genetic factors,environmental factors,and neurobiological factors all play a role in its pathogenesis.As an important external environment in the growth of children and adolescents,family plays an irreplaceable role in the formation of individual personality and physical and mental health.This paper elaborates the mechanism of BPD from the perspectives of biological genetics,family environment and gene-environment interaction,and summarizes some shortcomings and challenges faced by the current related research fields,hoping to provide new ideas for further research,and reference for clinical treatment and early intervention.