柴胡桂枝汤联合短期激素补充治疗围绝经期综合征的临床观察

Clinical Observation on the Combination of Chaihu Guizhi Decoction and short-term Hormone Supplementation in the Treatment of perimenopausal Syndrome

目的探讨柴胡桂枝汤联合短期激素补充治疗围绝经期综合征的临床效果。方法选取2019年1月至2020年8月在郑州市金水区总医院妇科门诊接受治疗的80例围绝经期综合征患者,按照随机数字表达法分为研究组(40例,柴胡桂枝汤联合短期激素补充治疗)与对照组(40例,短期激素补充治疗),观察治疗前、后患者内分泌水平、症状及子宫内膜厚度变化情况,比较两组患者的治疗效果与不良反应发生率。结果治疗前两组卵泡雌激素(FSH)、雌二醇(E_(2))水平比较,差异无统计学意义(P>0.05);治疗后,研究组FSH水平显著低于对照组,E_(2)水平显著高于对照组,差异有统计学意义(P<0.05)。治疗前两组症状评分、子宫内膜厚度比较,差异无统计学意义(P>0.05);治疗后,研究组症状得分低于对照组,子宫内膜厚度明显高于对照组,差异有统计学意义(P<0.05)。研究组治疗有效率显著高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。治疗前两组焦虑抑郁量表评分比较,差异无统计学意义(P>0.05);治疗后,研究组焦虑、抑郁评分低于对照组,差异有统计学意义(P<0.05)。治疗前两组匹兹堡睡眠质量指数(PSQI)评分比较,差异无统计学意义(P>0.05);治疗后研究组患者PSQI低于对照组,差异有统计学意义(P<0.05)。结论柴胡桂枝汤联合短期激素补充治疗围绝经期综合征能够调节激素分泌,改善临床症状,效果确切且安全。

Objective To explore the clinical effect of Chaihu Guizhi decoction combined with short-term hormone supplementation in the treatment of perimenopausal syndrome.Method A total of 80 patients with perimenopausal syndrome who received treatment at the gynecology clinic of Jinshui District General Hospital in Zhengzhou City from January 2019 to August 2020 were randomLy divided into a study group(40 cases,Chaihu Guizhi decoction combined with short-term hormone supplementation treatment)and a control group(40 cases,short-term hormone supplementation treatment)according to the expression of random numbers.Endocrine levels,symptoms,and changes in endometrial thickness of the patients were observed before and after treatment,the treatment efficacy and incidence of adverse reactions between two groups of patients were compared.Results Before treatment,there was no statistically significant difference in the levels of follicle estrogen(FSH)and estradiol(E_(2))between the two groups(P>0.05);After treatment,the FSH level in the study group was significantly lower than that in the control group,and the E_(2) level was significantly higher than that in the control group,with a statistically significant difference(P<0.05).There was no statistically significant difference in symptom scores and endometrial thickness between the two groups before treatment(P>0.05);After treatment,the symptom score of the study group was lower than that of the control group,and the endometrial thickness was significantly higher than that of the control group,with a statistically significant difference(P<0.05).The effective rate of treatment in the study group was significantly higher than that in the control group,with a statistically significant difference(P<0.05);There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).There was no statistically significant difference in the scores of the anxiety and depression scales between the two groups before treatment(P>0.05);After treatment,the anxiety and depression scores of the study group were lower than those of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the Pittsburgh Sleep Quality Index(PSQI)scores between the two groups before treatment(P>0.05);After treatment,the PSQI of the study group patients was lower than that of the control group,with a statistically significant difference(P<0.05).Conclusion Chaihu Guizhi decoction combined with short-term hormone supplementation can regulate hormone secretion,improve clinical symptoms,and have a definite and safe effect in the treatment of perimenopausal syndrome.