强化阿托伐他汀联合法舒地尔治疗冠状动脉慢血流患者的临床观察

Clinical observation of intensified atorvastatin combined with fasudil in the treatment of patients with coronary slow blood flow

目的探讨强化阿托伐他汀联合法舒地尔治疗冠状动脉慢血流(CSF)患者的临床疗效。方法选取2020年2月至2021年2月本院内科收治的87例因胸痛入院确诊为CSF患者作为研究对象,根据就诊单双数分为观察组(n=43)与对照组(n=44)。对照组给予强化阿托伐他汀治疗,观察组在对照组基础上联合法舒地尔治疗,比较两组治疗后心绞痛改善情况、治疗前后血管活性物质[一氧化氮(NO)及内皮素-1(ET-1)]水平及冠状动脉血流动速度[矫正心肌梗死溶栓试验(TIMI)]、血脂指标[总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL)]及不良反应发生率。结果观察组治疗总有效率为95.35%,高于对照组的79.55%,差异有统计学意义(P<0.05)。治疗后,两组NO水平均高于治疗前,ET-1水平均低于治疗前,且观察组NO水平高于对照组,ET-1水平低于对照组,差异有统计学意义(P<0.05)。治疗后,两组矫正TIMI值均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组TC、TG、LDL水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论强化阿托伐他汀联合法舒地尔治疗CSF效果显著,可调节血管活性物质水平,加快冠状动脉血液流动速度,改善血脂水平,治疗安全性较高。

Objective To explore the clinical efficacy of intensified atorvastatin combined with fasudil in the treatment of patients with coronary slow flow(CSF).Methods A total of 87 patients who diagnosed with CSF for chest pain admitted to the department of Internal Medicine of our hospital from February 2020 to February 20201 were selected as the study subjects,and they were divided into the observation group(n=43)and the control group(n=44)according to the odd and even number of visits.The control group was given intensified atorvastatin,and the observation group was given fasudil on the basis of the control group,the improvement of angina pectoris after treatment,the levels of vasoactive substances(nitric oxide[NO]and endothelin-1[ET-1]),and the coronary blood flow velocity(corrected thrombolysis in myocardial infarction[TIMI]),lipid indexes(total cholesterol[TC],triglyceride[TG],low-density lipoprotein[LDL]),and the incidence of adverse reactions were compared between the two groups.Results The total effective rate in the observation group was 95.35%,which was higher than 79.55%in the control group,the difference was statistically significant(P<0.05).After treatment,the NO levels of the two groups were higher than before treatment,ET-1 levels were lower than before treatment,and the level of NO in the observation group was higher than that in the control group,and the level of ET-1 was lower than that in the control group,the differences were statistically significant(P<0.05).After treatment,the corrected values of TIMI of the two groups were lower than before treatment,and the observation group was lower than the control group,the differences were statistically significant(P<0.05).After treatment,the levels of TC,TG and LDL of the two groups were lower than those before treatment,and the observation group was lower than the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Intensified atorvastatin combined with fasudil has positive effect in the treatment of CSF,which can regulate the level of vasoactive substances and accelerate the speed of coronary blood flow,improve blood lipid levels,and has high therapeutic safety.