小柴胡汤联合化疗治疗复发转移晚期乳腺癌临床观察

Xiaochaihu Decoction Combined with Chemotherapy in the Treatment of Relapsed and Metastatic Advanced Breast Cancer

目的 以复发转移晚期乳腺癌患者为对象,探究小柴胡汤联合化疗的临床效果及对肿瘤标志物的影响。方法 选取2018年6月—2020年6月营口市中医院收治的82例复发转移晚期乳腺癌患者,以数字号形式随机分为对照组、观察组,各41例。对照组患者行化疗,观察组患者行化疗和小柴胡汤联合治疗。以疗效、肿瘤标志物、不良反应发生率为判定指标,对2组进行分析。结果 观察组总有效率为82.93%(34/41),高于对照组的63.41%(26/41),差异有统计学意义(P<0.05)。观察组肿瘤标志物数据评分结果较对照组更低,差异有统计学意义(P<0.05)。观察组不良反应发生率为24.39%(10/41),低于对照组的51.22%(21/41),差异有统计学意义(P<0.05)。结论 对复发转移晚期乳腺癌患者行化疗与小柴胡汤联合治疗,能有效改善患者病情,防止病情进展,肿瘤标志物分泌减少,不良反应发生减少,安全性高。

Objective To investigate the clinical effect of Xiaochaihu decoction combined with chemotherapy and its influence on tu-mor markers in patients with relapsed and metastatic advanced breast cancer.Methods The 82 patients with relapsed and metastatic advanced breast cancer accepted by Yingkou Hospital of Traditional Chinese Medicine from June 2018 to June 2020 were selected as subjects,and the selected cases of the study were randomly assigned in the form of numbers,namely the control group of 41 cases and the observation group of 41 cases.Chemotherapy was chosen for patients in the control group,and chemotherapy and Xiaochaihu de-coction were given to patients in the observation group.Based on the therapeutic effect,tumor markers,and adverse reaction rates,the results are analyzed for different treatments.Results The total effective rate of the observation group was 82.93%(34/41),which was higher than that of the control group(63.41%,26/41),and the difference was statistically significant(P<0.05).The tumor marker data score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).The in-cidence of adverse reactions in the observation group was 24.39%(10/41),which was lower than that in the control group(51.22%,21/41),and the difference was statistically significant(P<0.05).Conclusion Xiaochaihu decoction combined with chemotherapy in the treatment of relapsed and metastatic advanced breast cancer can effectively improve the patient’s condition,prevent the disease from spreading,reduce the secretion of tumor markers,reduce the occurrence of adverse reactions after treatment,and have high safety.