血必净注射液联合莫西沙星治疗重症肺炎的疗效及对患者肺功能与炎症指标的影响

Effect of Xuebijing injection combined with moxifloxacin in the treatment of severe pneumonia and its influence on lung function and inflammatory indicators of patients

目的探究血必净注射液联合莫西沙星治疗重症肺炎的疗效及对患者肺功能与炎症指标的影响。方法选取2019年6月至2020年9月本院收治的92例重症肺炎患者作为研究对象,按照随机数字表法分为对照组与观察组,每组46例。两组均给予基础治疗,对照组给予莫西沙星治疗,观察组在对照组基础上联合血必净注射液治疗,比较两组临床症状消失时间、住院时间、肺功能指标[最大吸气压(PI_(max))、最大呼气压(PE_(max))、呼气峰流速(PEF)、最大呼气中段流量(MMF)]及炎症指标[白细胞介素-6(IL-6)、肿瘤坏死因子(TNF-α)、C反应蛋白(CRP)]。结果观察组肺部啰音、咳嗽、发热、气促症状消失时间及住院时间均短于对照组,差异有统计学意义(P<0.05)。治疗前,两组PI_(max)、PE_(max)、PEF、MMF比较差异无统计学意义;治疗后,两组PI_(max)、PE_(max)、PEF、MMF均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗前,两组IL-6、TNF-α、CRP水平比较差异无统计学意义;治疗后,两组IL-6、TNF-α、CRP水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论血必净注射液联合莫西沙星治疗重症肺炎疗效显著,可明显缓解患者临床症状,抑制炎症反应,改善肺功能,值得临床推广应用。

Objective To explore the efficacy of Xuebijing injection combined with moxifloxacin in the treatment of severe pneumonia and its influence on lung function and inflammatory indicators of patients.Methods A total of 92 patients with severe pneumonia admitted to our hospital from June 2019 to September 2020 were selected as the research subjects,and they were divided into the control group and the observation group according to random number table method,with 46 cases in each group.Both groups were given basic treatment,the control group was given moxifloxacin treatment,and the observation group was combined with Xuebijing injection on the basis of the control group,the clinical symptom disappearance time,hospital stay,lung function indicators(_(max)imum inspiratory pressure[PI_(max)],_(max)imum expiratory pressure[PE_(max)],peak expiratory flow[PEF],_(max)imum mid-expiratory flow[MMF])and inflammatory indicators(interleukin-6[IL-6],tumor necrosis factor-α[TNF-α],C-reactive protein[CRP])were compared between the two groups.Results The disappearance time of lung rales,cough,fever and shortness of breath and hospital stay in the observation group were significantly shorter than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant difference in PI_(max),PE_(max),PEF and MMF between the two groups;after treatment,PI_(max),PE_(max),PEF and MMF of the two groups were higher than those before treatment,and the observation group was significantly higher than the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of IL-6,TNF-αand CRP between the two groups;after treatment,the levels of IL-6,TNF-αand CRP of the two groups were lower than those before treatment,and the observation group were significantly lower than the control group,and the differences were statistically significant(P<0.05).Conclusion Xuebijing injection combined with moxifloxacin is effective in the treatment of severe pneumonia,which can significantly relieve clinical symptoms,inhibit inflammatory response and improve lung function,which is worthy of clinical promotion and application.