血清淀粉样蛋白A和超敏C反应蛋白与慢性阻塞性肺疾病患者病情程度及预后的相关性研究

Correlation of serum amyloid A and hypersensitive Creactive protein with the severity and prognosis of chronic obstructive pulmonary disease

目的探究血清淀粉样蛋白A(SAA)、超敏C反应蛋白(hs-CRP)与慢性阻塞性肺疾病(COPD)患者病情程度及预后的相关性。方法回顾性选取2020年6月至2021年4月于本院就诊治疗的103例COPD患者作为研究组,并选取同期50名健康人群作为对照组。收集两组临床资料,分析血清SAA、hs-CRP与COPD患者病情程度及预后的相关性。结果入院时,研究组血清SAA、hs-CRP水平均明显高于对照组,差异有统计学意义(P<0.05)。研究组急性期患者血清SAA、hs-CRP水平均明显高于稳定期患者,差异有统计学意义(P<0.05)。研究组预后不良患者血清SAA、hs-CRP水平均明显高于预后良好患者,差异有统计学意义(P<0.05)。二元Logistics回归分析显示,血清SAA、hs-CRP水平高是导致COPD患者病情加重、预后不良的危险因素(P<0.05)。结论血清SAA、hs-CRP水平与COPD患者病情程度和预后密切相关,监测血清SAA、hs-CRP水平对于COPD的诊治和预后具有重要意义。

Objective To investigate the correlation of serum amyloid A(SAA)and hypersensitive C-reactive protein(hs-CRP)with the severity and prognosis of chronic obstructive pulmonary disease(COPD).Methods A total of 103 patients with COPD who were treated in our hospital from June 2020 to April 2021 were selected as the study group,at the same time,50 healthy individuals were selected as the control group.The clinical data of the two groups were collected,the correlation of serum SAA and hs-CRP with the severity and prognosis of COPD was analyzed.Results On admission,the levels of serum SAA and hs-CRP in the study group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of serum SAA and hs-CRP in the acute phase of the study group were significantly higher than those in the stable phase,and the differences were statistically significant(P<0.05).The levels of serum SAA and hs-CRP in patients with poor prognosis in the study group were significantly higher than those in patients with good prognosis,and the differences were statistically significant(P<0.05).Binary Logistics regression analysis showed that high levels of serum SAA and hs-CRP were risk factors for exacerbation and poor prognosis in patients with COPD(P<0.05).Conclusion Serum SAA and hs-CRP levels are closely related to the severity and prognosis of COPD,monitoring serum SAA and hs-CRP levels is of great significance for the diagnosis,treatment,and prognosis of COPD.