癫痫相关自身抗体研究进展

Research progress of epilepsy-related autoantibodies

随着神经特异性自身抗体的发现,自身免疫性癫痫研究领域已经有了实质性的发展。相当比例的癫痫发作由自身免疫反应介导。自身免疫性癫痫患者多以新发难治性癫痫伴亚急性进行性认知功能减退及行为或精神功能障碍为主。自身免疫性癫痫的提出,阐明了癫痫的免疫学基础,为神经病学家提供除抗癫痫药物外更广泛的治疗选择,即免疫治疗。本文就几种可能与自身免疫性癫痫有关的神经自身抗体进行系统性综述。

With the discovery of neurospecific autoantibodies,the field of autoimmune epilepsy research has made substantial progress.A significant proportion of seizures are mediated by autoimmune responses.The majority of patients with autoimmune epilepsy usually present with new-onset refractory epilepsy along with subacute progressive cognitive decline and behavioral or mental dysfunction.The proposal of autoimmune epilepsy clarifies the immunological basis of epilepsy and provides neurologists with a wider choice of treatment besides antiepileptic drugs,namely immunotherapy.This article systematically reviews several autoantibodies that may be related to autoimmune epilepsy.