瓜蒌止咳化痰汤联合布地奈德雾化吸入治疗慢性阻塞性肺疾病的临床研究

Clinical study of Gualsanthis Zhike Huatan decoction combined with budesonide aerosol inhalation in the treatment of chronic obstructive pulmonary disease

目的探究瓜蒌止咳化痰汤联合布地奈德雾化吸入治疗慢性阻塞性肺疾病(COPD)的疗效及安全性。方法选取2019年1月至2020年1月本院收治的82例COPD患者作为研究对象,按照随机数字表法分为观察组与对照组,每组41例。对照组予以布地奈德治疗,观察组在对照组基础上联合瓜蒌止咳化痰汤治疗,比较两组临床疗效、肺功能[第1秒用力呼气容积(FEV_(1))的实测值与预计值的比值(FEV_(1)%)、FEV_(1)占用力肺活量(FVC)比值(FEV_(1)/FVC)]与血气分析指标[动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))]及不良反应发生情况。结果观察组治疗总有效率为92.68%,高于对照组的70.73%,差异有统计学意义(P<0.05)。治疗前,两组FEV_(1)%、FEV_(1)/FVC比较差异无统计学意义;治疗后,两组FEV_(1)%、FEV_(1)/FVC均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗前,两组PaCO_(2)、PaO_(2)比较差异无统计学意义;治疗后,两组PaCO_(2)均低于治疗前,PaO_(2)均高于治疗前,且观察组PaCO_(2)低于对照组,PaO_(2)高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论瓜蒌止咳化痰汤联合布地奈德雾化吸入治疗COPD效果确切,可明显改善患者肺功能及血液氧合能力,安全性较高,值得临床推广应用。

Objective Clinical study of Gualsanthis Zhike Huatan decoction combined with budesonide aerosol inhalation in the treatment of chronic obstructive pulmonary disease(COPD).Methods A total of 82 patients with COPD admitted to our hospital from January 2019 to January 2020 were selected as the research subjects,and they were divided into the observation group and the control group according to random number table method,with 41 cases in each group.The control group was treated with budesonide,and the observation group was treated with Gualsanthis Zhike Huatan decoction on the basis of the control group,the clinical efficacy,lung function index(ratio of measured value of forced expiratory volume in one second[FEV_(1)]to predicted value[FEV_(1)%],ratio of FEV_(1)to forced vital capacity[FVC][FEV_(1)/FVC]),blood gas analysis(partial pressure of oxygen[PaO_(2)],partial pressure of carbon dioxide[PaCO_(2)])and adverse reactions were compared between the two groups.Results The total effective rate in the observation group was 92.68%,which was higher than 70.73%in the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in FEV_(1)%and FEV_(1)/FVC between the two groups;after treatment,the FEV_(1)%and FEV_(1)/FVC of two groups were higher than before treatment,and the observation group was higher than the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in PaCO_(2)and PaO_(2)between the two groups;after treatment,the PaCO_(2)of the two groups was lower than before treatment,the PaO_(2)was higher than before treatment,and PaCO_(2)in the observation group was lower than in the control group,PaO_(2)was higher than the in control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Gualsanthis Zhike Huatan decoction combined with budesonide atomizing inhalation has a definite effect in the treatment of COPD,which can significantly improve lung function and blood oxygenation ability of patients,with high safety,and is worthy of clinical application.