摘要
目的分析腹腔镜卵巢囊肿剥除术对卵巢囊肿患者IgM、IgG、CD4^(+)/CD8^(+)及性激素水平的影响。方法选取2018年5月至2021年5月本院收治的80例卵巢囊肿患者作为研究对象,根据治疗方法不同分为对照组与观察组,每组40例。对照组采用开腹卵巢囊肿剥除术治疗,观察组采用腹腔镜卵巢囊肿剥除术治疗,比较两组手术前后免疫指标(IgM、IgG、CD4^(+)/CD8^(+))及性激素[抗苗勒管激素(AMH)、促黄体激素(LH)、促卵泡激素(FSH)、雌二醇(E_(2))]水平。结果术前,两组IgM、IgG水平及CD4^(+)/CD8^(+)比较差异无统计学意义;术后3 d,观察组IgM、IgG水平及CD4^(+)/CD8^(+)与术前比较差异无统计学意义,对照组IgM、IgG水平及CD4^(+)/CD8^(+)均低于术前,而观察组IgM、IgG、CD4^(+)/CD8^(+)水平均高于对照组,差异有统计学意义(P<0.05)。术前,两组AMH、LH、FSH、E_(2)水平比较差异无统计学意义;术后1个月,两组LH、FSH水平均高于术前,AMH、E_(2)水平均低于术前,但观察组LH、FSH水平均低于对照组,AMH、E_(2)水平均高于对照组,差异有统计学意义(P<0.05)。结论与传统开腹卵巢囊肿剥除术相比,腹腔镜卵巢囊肿剥除术在稳定卵巢囊肿患者自身免疫功能、近期卵巢功能方面的优势显著,值得临床推广应用。
Objective To analyze the effects of laparoscopic ovarian cyst removal on the levels of IgM,IgG,CD4^(+)/CD8^(+)and sex hormones in patients with ovarian cyst.Methods 80 patients with ovarian cyst admitted to our hospital from May 2018 to May 2021 were selected as the research subjects,and they were divided into the control group and the observation group according to different treatment methods,with 40 cases in each group.The control group was treated with open ovarian cystectomy,and the observation group was treated with laparoscopic ovarian cyst excision,the levels of immune indexes(IgM,IgG,CD4^(+)/CD8^(+))and sex hormones(anti-mullerian hormone[AMH],luteinizing hormone[LH],follicle stimulating hormone[FSH],estradiol[E_(2)])before and after operation were compared between the two groups.Results Before operation,there were no significant differences of IgM,IgG and CD4^(+)/CD8^(+)levels between the two groups;3 d after operation,the levels of IgM,IgG and CD4^(+)/CD8^(+)in the observation group were not statistically significant compared with those before operation,the levels of IgM,IgG and CD4^(+)/CD8^(+)in the control group were lower than those before operation,but the levels of IgM,IgG and CD4^(+)/CD8^(+)in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Before operation,there was no significant difference of AMH,LH,FSH and E_(2)levels between the two groups;1 month after operation,the levels of LH and FSH of the two groups were higher than those before operation,and the levels of AMH and E_(2)were lower than those before operation,but the levels of LH and FSH in the observation group were lower than those in the control group,and the levels of AMH and E_(2)were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion Compared with traditional laparotomy,laparoscopic ovarian cyst excision has significant advantages in stabilizing the autoimmune function and short-term ovarian function in patients with ovarian cyst,and is worthy of clinical promotion application.
作者
黎哲文
彭幼
陈美琼
LI Zhewen;PENG You;CHEN Meiqiong(Department of Gynecology,Shanwei People's Hospital,Shanwei,Guangdong,516600,China)
出处
《当代医学》
2023年第17期88-91,共4页
Contemporary Medicine