海藻酸钠微球的制备及应用研究进展

Progress in preparation and application of sodium alginate microspheres

海藻酸钠(SA)是从褐藻类海带中提取的一种天然高分子材料,具备出色的生物相容性、无毒性、生物降解性以及丰富的储存量。海藻酸钠凝胶形成的条件温和,可有效避免活性物质的失活。经过多种制备方法,海藻酸钠微球被广泛用于生物材料和组织工程等领域。本文综述了制备海藻酸钠微球的常见方法,包括挤出法、乳化法、静电喷射法、喷雾干燥法和同轴气流法,并探讨了它在骨修复、止血以及药物递送等生物医学领域的应用。

Sodium alginate(SA)is a kind of natural polymer material extracted from kelp,which has excellent biocompatibility,non-toxicity,biodegradability and abundant storage capacity.The formation condition of sodium alginate gel is mild,effectively avoiding the inactivation of active substances.After a variety of preparation methods,sodium alginate microspheres are widely used in the fields of biomaterials and tissue engineering.This paper reviewed the common methods of preparing alginate microspheres,including extrusion,emulsification,electrostatic spraying,spray drying and coaxial airflow,and discussed their applications in biomedical fields such as bone repair,hemostasis and drug delivery.