微小RNA调控细胞自噬在幽门螺旋杆菌感染过程中的研究进展

Progress in regulation of cellular autophagy by microRNAs during Helicobacter pylori infection

幽门螺旋杆菌在1994年被世界卫生组织(WHO)列为Ⅰ类致癌因子,常诱导慢性胃炎、消化性溃疡等疾病的发生,并且可能促进胃癌的发展[1-2]。深入研究幽门螺旋杆菌慢性感染机制和致病机理及其对宿主的保护免疫反应的逃避效应,对于疾病的预防、诊断和治疗都有重要意义。自噬作为细胞程序化死亡方式之一,其过程主要经历吞噬泡的形成、自噬小体的形成、自噬体与溶酶体的结合、细胞内容物的降解,其实质是溶酶体依赖的蛋白质降解途径[3]。

Helicobacter pylori,as one of the most prevalent bacteria worldwide,survives in the host for prolonged periods of time and induces chronic gastritis,peptic ulcers,and other diseases.Autophagy is a cellular degradation mechanism,which is involved in Helicobacter pylori infection and that involves the modulation of the host environment by bacterial virulence factors.MicroRNAs(miRNAs)are a class of endogenous small noncoding RNAs that play an important role in cell autophagy,apoptosis,immunity,and inflammation during Helicobacter pylori infection.Several studies have confirmed that Helicobacter pylori infection induces differential expression of miRNA,which participates in modulating cellular autophagy.Therefore,this paper mainly reviews the research progress on miRNAs involved in the regulation of autophagy during Helicobacter pylori infection,and focuses on the mechanisms of several miRNAs involved in the regulation of autophagy,providing possible ideas and strategies for the treatment of corresponding diseases.