单端孢霉烯族毒素诱导动物拒食反应机制研究进展

Research progress on the mechanisms of trichothecenes-induced anorexia in animals

对单端孢霉烯族毒素(trichothecenes,TS)进行了概述,重点对A型和B型TS诱导动物拒食反应机制,包括迷走神经、胃肠道激素、神经递质和细胞因子在TS引起拒食反应中发挥的作用进行了综述,为预防和治疗由TS引起动物拒食等临床症状提供理论依据和参考。目前,TS引起拒食反应的研究尚处于起步阶段,拒食反应的分子机制有待进一步探究。相关研究应重点关注胃肠道激素及神经系统在TS引起拒食反应中的作用,以进一步揭示其分子机制。

This paper summarizes trichothecenes(TS),with emphasis on the mechanism of animal anorexia response induced by type A and type B of TS,including the roles of vagus nerve,gastrointestinal hormones,neurotransmitters and cytokines in antifeedant reaction induced by TS.The study will provide a theoretical basis and reference for the prevention and treatment of animal anti-feeding symptoms caused by TS.At present,the study of anorexia reaction induced by TS is still in the initial stage,and the molecular mechanism of anorexia reaction needs to be further explored.In the future,relevant studies should focus on the roles of gastrointestinal hormones and nervous system in anorexia reaction induced by TS to further reveal its molecular mechanism.