甲状腺乳头状癌TERT启动子突变与颈部淋巴结转移关系的Meta分析

Evaluation of the relationship between TERT promoter mutation and cervical lymph node metastasis in papillary thyroid carcinoma:a meta-analysis

目的采用Meta分析评价甲状腺乳头状癌患者端粒酶逆转录酶启动子(TERTp)突变与颈部淋巴结转移之间的关系。方法检索PubMed、the Cochrane Library、Embase数据库、Web of Science、中国知网数据库、万方全文数据库,搜集甲状腺乳头状癌患者携带TERTp突变的病例对照研究或队列研究,检索截至2023年7月。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,使用Review Manager 5.4和STATA 17.0进行Meta分析。结果共检出文献369篇,最终纳入33项研究,包括12683例患者。Meta分析表明,携带TERTp突变的PTC患者较未发生TERTp突变的PTC患者,发生颈部淋巴结转移的风险更高。结论TERTp突变会增加PTC患者颈部淋巴结转移风险,是预测PTC患者发生淋巴结转移的重要参考因素。

Objective To evaluate the relationship between telomerase reverse transcriptase promoter(TERTp)mutation and cervical lymph node metastasis in patients with papillary thyroid carcinoma(PTC)by meta-analysis.MethodsCase-control or cohort studies of TERTp mutations in PTC patients were electronically searched from PubMed,the Cochrane Library,Embase,Web of Science,China National Knowledge Internet(CNKI)and Wanfang databases up to July 2023.Two reviewers independently screened the literature,from which the data were extracted and assessed the risk of bias of the included studies.Review Manager 5.4 and STATA 17.0 were used for meta-analysis.Results A total of 369 papers were retrieved,and 33 studies were finally included,including 12683 patients.The meta-analysis showed that the PTC patients carrying TERTp mutations had a higher risk of cervical lymph node metastasis than those without TERTp mutations.Conclusion TERTp mutation increases the risk of cervical lymph node metastasis in PTC patients and is an important reference factor in predicting lymph node metastasis in the PTC patients.