基于体素形态学测量的首发精神分裂症幻听患者全脑白质体积研究

A study on whole brain white matter volume based on voxel-based morphometry in first-episode schizophrenia patients with auditory verbal hallucination

目的 采用基于体素的形态学测量方法探讨首发精神分裂症(SCH)幻听患者的全脑白质体积变化情况。方法 纳入在空军军医大学西京医院心身科就诊的首发SCH幻听患者25人作为患者组,来自广告募集的健康人群25人作为对照组,行磁化准备快速梯度回波序列扫描,使用基于体素的形态学测量方法研究首发SCH幻听患者的全脑白质体积变化情况。结果 与对照组相比,患者组白质体积增加的区域位于布洛卡区周围,而体积减少的区域位于右侧扣带回周围及放射冠区。布洛卡区周围白质体积和阳性与阴性症状量表的阳性症状评分呈正相关关系(r=0.588,P<0.01)。结论 首发SCH幻听患者的多个脑区白质体积存在异常,其前额中回周围白质体积的增加可能是SCH幻听患者脑损害的潜在神经影像学标志。

Objective To investigate the changes of whole brain white matter volume in first-episode schizophrenia(SCH)patients with auditory verbal hallucination using voxel-based morphometry(VBM).Methods Twenty-five first-episode SCH patients with auditory verbal hallucination in Department of Psychosomatic Medicine,Xijing Hospital,Air Force Medical University were included as patient group,and 25 healthy subjects recruited from the advertisement were selected as control group.Magnetization-prepared rapid gradient-echo sequence was performed and VBM method was used to study the changes of whole brain white matter volume in first-episode SCH patients with auditory verbal hallucination.Results Compared with the control group,the area of increased white matter volume in the patient group was located around Broca s area,while that of decreased white matter volume was located around the right cingulate gyrus and the corona radiata area.There was a positive correlation between the white matter volume around Broca s area and the positive symptom score of Positive and Negative Syndrome Scale(r=0.588,P<0.01).Conclusion The white matter volume in multiple brain regions is abnormal in first-episode SCH patients with auditory verbal hallucination.The increase of white matter volume around the middle prefrontal gyrus may be a potential neuroimaging marker of brain damage in SCH patients with auditory verbal hallucination.