308 nm准分子激光及308 nm准分子光治疗白癜风皮损复色模式分析

Analysis of repigmentation patterns in vitiligo lesions treated by 308-nm excimer lamp and 308-nm excimer laser

目的 总结308 nm准分子激光及308 nm准分子光治疗白癜风皮损的复色模式,并分析影响复色模式的因素。方法 共纳入白癜风患者79(男39,女40)例,共观察记录143块皮损,对143块皮损按照常规治疗方案分为308 nm准分子激光治疗组和308 nm准分子光治疗组,每个月评价白癜风皮损的复色模式1次,连续记录3次,并于6个月后重复评价1次;采集患者基本信息及白癜风病情相关指标,分析白癜风患者临床信息与复色模式的相关性。结果 治疗后,62块(43.3%)皮损呈现毛囊周围型复色模式,40块(28.0%)皮损呈现边缘型复色模式,30块(21.0%)皮损呈现混合型复色模式,11块(7.7%)皮损呈现弥漫型复色模式。年龄、病程、解剖学部位不影响白癜风复色的模式。结论 使用308 nm准分子激光及308 nm准分子光治疗白癜风皮损复色模式之间无明显差异,均以毛囊周围型为主。

Objective To summarize the repigmentation patterns in vitiligo lesions treated by 308-nm excimer laser and 308-nm excimer lamp,and to analyze the factors affecting the repigmentation patterns.Methods A total of 79 vitiligo patients(39 males and 40 females)were enrolled in the study.A total of 143 lesions were observed and recorded,and they were divided into 308-nm excimer laser therapy group and 308-nm excimer lamp therapy group,according to the conventional treatment plan.The repigmentation patterns in vitiligo lesions were evaluated once a month and recorded 3 consecutive times,and the evaluation was repeated 6 months later.The basic information and related indicators of vitiligo were collected to analyze the correlation between clinical information and repigmentation patterns of vitiligo patients.Results After treatment,62 lesions(43.3%)showed perifollicular repigmentation pattern,40 lesions(28.0%)showed marginal repigmentation pattern,30 lesions(21.0%)showed combined repigmentation pattern,and 11 lesions(7.7%)showed diffuse repigmentation pattern.Age,course of disease and anatomical location did not affect the repigmentation patterns of vitiligo.Conclusion There is no significant difference in vitiligo lesions treated by 308-nm excimer laser and 308-nm excimer lamp,and both are mainly perifollicular repigmentation pattern.