H型高血压对冠心病患者左心室收缩功能的影响

The influence of H-type hypertension on left ventricular systolic function in patients with coronary heart disease

目的探讨H型高血压对冠心病患者左心室收缩功能的影响。方法选取2018年4月至2020年4月本院收治的96例高血压合并冠心病患者作为研究对象,按照血同型半胱氨酸(Hcy)水平分为分析组(Hcy>10μmol/L,n=52)和对照组(Hcy≤10μmol/L,n=44),分析组为H型高血压合并冠心病,对照组为单纯高血压合并冠心病。另将患者按照左心室射血分数(LVEF)分为左心室功能障碍Ⅰ组(LVEF≥0.4,n=47)和左心室功能障碍Ⅱ组(LVEF<0.4,n=49)。分析H型高血压对冠心病患者左心室收缩功能的影响。结果分析组与对照组性别、年龄、病程、血糖(GLu)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)、体重指数(BMI)比较差异无统计学意义,分析组血浆N末端脑钠肽前体浓度(NT-proBNP)、血同型半胱氨酸(Hcy)水平高于对照组,LVEF低于对照组,差异有统计学意义(P<0.05);左心室功能障碍Ⅰ组与左心室功能障碍Ⅱ组年龄、GLu、LDL-C、TC、BMI比较差异无统计学意义,左心室功能障碍Ⅱ组H型高血压发生率高于左心室功能障碍Ⅰ组,HDL-C低于左心室功能障碍Ⅰ组,差异统计学意义(P<0.05);Logistic回归分析结果显示,H型高血压是冠心病患者左心室收缩功能的独立影响因素(P<0.05)。结论H型高血压可直接影响冠心病患者的左心室收缩功能,治疗H型高血压合并冠心病时,不仅要控制患者血压,还需降低患者血Hcy水平,改善患者左心室收缩功能,减缓患者病情发展。

Objective To investigate the effect of H-type hypertension on left ventricular systolic function in patients with coronary heart disease.Methods 96 patients with hypertension and coronary heart disease admitted to our hospital from April 2018 to April 2020 were selected as the research subjects,and they were divided into analysis group(Hcy>10μmol/L,n=52)and control group(Hcy≤10μmol/L,n=44)according to blood homocysteine level.The analysis group was H-type hypertension combined with coronary heart disease,and the control group was simple hypertension combined with coronary heart disease.In addition,the patients were divided into left ventricular disorderⅠgroup(LVEF≥0.4,n=47)and left ventricular disorderⅡgroup(LVEF<0.4,n=49)according to left ventricular ejection fraction(LVEF).To analyze the effect of H-ype hypertension on left ventricular systolic function in patients with coronary heart disease.Results There was no statistical significance in gender,age,course of disease,blood glucose(GLu),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),total cholesterol(TC)and body mass index(BMI)between analysis group and control group,N terminal pro B type natriuretic peptide(NT-proBNP)and homocysteine(Hcy)in the analysis group were higher than those in the control group,and LVEF was lower than that in the control group,the differences were statistically significant(P<0.05).There was no significant difference in gender,age,GLu,LDL-C,TC and BMI between left ventricular disorderⅠgroup and left ventricular disorderⅡgroup,the incidence of H-type hypertension and Hcy of left ventricular disorderⅡgroup was higher than that of left ventricular disorderⅠgroup,and HDL-C was lower than that of left ventricular disorderⅠgroup,and the difference was statistically significant(P<0.05).Logistic regression analysis showed that H-type hypertension was an independent factor affecting left ventricular systolic function in patients with coronary heart disease.Conclusion H-type hypertension can directly affect the left ventricular systolic function in patients with coronary heart disease,in the treatment of H-type hypertension combined with coronary heart disease,blood pressure should be controlled,blood Hcy level should be reduced,left ventricular systolic function should be improved,and disease development should be slowed down.