胸腺肽联合抗生素治疗老年慢性阻塞性肺疾病急性加重期的临床效果

Clinical efficacy of thymosin combined with antibiotics in the treatment of elderly patients with acute exacerbation of chronic obstructive pulmonary disease

目的探讨胸腺肽联合抗生素治疗老年慢性阻塞性肺疾病急性加重期(AECOPD)患者的临床效果。方法选取2019年1月至2020年12月于本院接受治疗的90例老年AECOPD患者作为研究对象,根据不同的治疗方案分为两组,将单一应用抗生素治疗的患者作为参照组,应用抗生素联合胸腺肽治疗的患者作为研究组,每组45例。比较两组治疗前后肺功能与免疫功能。结果治疗后,两组第1秒用力呼气容积(FEV1)、第1秒用力呼气量容积占用力肺活量比值(FEV1/FVC)均高于治疗前,且研究组高于参照组(P<0.05)。治疗后,两组CD3^(+)、CD4^(+)水平均高于治疗前,CD8^(+)水平低于治疗前,且研究组CD3^(+)、CD4^(+)水平高于参照组,CD8^(+)水平低于参照组(P<0.05)。结论胸腺肽联合抗生素治疗老年AECOPD患者疗效显著,可改善患者免疫功能、肺功能,值得临床推广应用。

Objective Explore the clinical efficacy of thymosin combined with antibiotics in the treatment of elderly patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 90 elderly patients with AECOPD who received treatment in our hospital from January 2019 to December 2020 were selected as research subjects,they were divided into two groups based on different treatment plans,with patients treated with antibiotics alone as the reference group and patients treated with antibiotics combined with thymosin as the study group,with 45 cases in each group.The lung function and immune function before and after treatment were compared between the two groups.Results After treatment,the forced expiratory volume in the first second(FEV1)and the ratio of forced expiratory volume to forced vital capacity in the first second(FEV1/FVC)in two groups were higher than those before treatment,and the study group was higher than the reference group(P<0.05).After treatment,the levels of CD3^(+)and CD4^(+)in two groups were higher than those before treatment,while the levels of CD8^(+)were lower than that before treatment,and the levels of CD3^(+)and CD4^(+)in the study group were higher than those in the reference group,and the levels of CD8^(+)were lower than those in the reference group(P<0.05).Conclusion The antibiotics combined with thymosin has significant therapeutic effect on elderly AECOPD patients,which can improve their immune function and lung function,and is worthy of clinical promotion and application.