急性脑梗死患者治疗前后血清同型半胱氨酸及超敏C反应蛋白的检测价值评价

Evaluation of serum homocysteine and hypersensitive Creactive protein in patients with acute cerebral infarction before and after treatment

目的探讨急性脑梗死患者治疗前后血清同型半胱氨酸(Hcy)及超敏C反应蛋白(hs-CRP)检测的价值。方法选取2019年3月至2020年9月吴川市人民医院神经内科二区收治的100例急性脑梗死患者作为实验组,另选取同期100名健康体检者作为参照组,比较两组Hcy、hs-CRP、血清白细胞介素-18(IL-18)、基质金属蛋白酶-9(MMP-9)、超氧化物歧化酶(SOD)、丙二醛(MDA)水平。结果治疗前,实验组Hcy、hs-CRP、IL-18、MMP-9水平高于参照组,差异有统计学意义(P<0.05);治疗后,实验组Hcy、hs-CRP、IL-18、MMP-9水平低于治疗前,但均高于参照组,差异有统计学意义(P<0.05)。治疗前,实验组SOD水平低于参照组,MDA水平高于参照组,差异有统计学意义(P<0.05);治疗后,实验组SOD水平高于治疗前,MDA水平低于治疗前,且实验组MDA水平低于参照组,差异有统计学意义(P<0.05)。结论急性脑梗死患者治疗前后检测Hcy、hs-CRP、IL-18、MMP-9、SOD、MDA水平具有重要意义,可为改善患者预后奠定基础。

Objective To investigate the value of serum homocysteine(Hcy)and hypersensitive C-reactive protein(hs-CRP)detection in patients with acute cerebral infarction before and after treatment.Methods 100 patients with acute cerebral infarction treated in the second District of the Department of Neurology of Wuchuan People's Hospital from March 2019 to September 2020 were selected as the experimental group,and 100 healthy subjects in the same period were selected as the reference group,the levels of Hcy,hs-CRP,serum interleukin 18(IL-18),matrix metalloproteinase 9(MMP-9),superoxide dismutase(SOD)and malondialdehyde(MDA)were compared between the two groups.Results Before treatment,the levels of Hcy,hs-CRP,IL-18 and MMP-9 in the experimental group were higher than those in the reference group,the differences were statistically significant(P<0.05);after treatment,the levels of Hcy,hs-CRP,IL-18 and MMP-9 in the experimental group were lower than before treatment,but higher than reference group,and the differences were statistically significant(P<0.05).Before treatment,the levels of SOD in experimental group was lower than that in reference group,the level of MDA was higher than that in reference group,the differences were statistically significant(P<0.05);after treatment,the level of SOD in experimental group was higher than before treatment,the levels of MDA was lower than before treatment,and MDA in experimental group was lower than reference group,and the differences were statistically significant(P<0.05).Conclusion Detection of Hcy,hs-CRP,IL-18,MMP-9,SOD and MDA before and after treatment in patients with acute cerebral infarction is great significance,which can lay foundation for improving the prognosis of patients.