血清血管内皮生长因子及单核细胞趋化蛋白-1水平与慢性肾衰竭患者血液透析治疗预后的相关性

Correlation between serum vascular endothelial growth factor and monocyte chemoattractant protein-1 level and the prognosis of hemodialysis in patients with chronic renal failure

目的探讨血清血管内皮生长因子(VEGF)、单核细胞趋化蛋白-1(MCP-1)与慢性肾衰竭(CRF)患者血液透析治疗预后的相关性。方法回顾性分析2016年1月至2020年8月本院收治的80例血液透析治疗预后不良CRF患者的临床资料,观察预后不良患者与预后良好患者血液透析治疗前血清VEGF、MCP-1水平,并分析血清VEGF、MCP-1水平与CRF患者血液透析治疗预后的相关性。结果预后不良患者血清VEGF、MCP-1水平均高于预后良好患者,差异有统计学意义(P<0.05);经Logistic回归分析结果显示,血清VEGF、MCP-1水平高可能是CRF患者血液透析预后不良的影响因素(OR>1,P<0.05)。结论血清VEGF、MCP-1水平与CRF患者血液透析治疗预后密切相关,血清VEGF、MCP-1水平越高,CRF血液透析治疗预后不良风险越高。

Objective To analyze the correlation between the prognosis of patients with chronic renal failure(CRF)treated with hemodialysis and serum vascular endothelial growth factor(VEGF)and monocyte chemoattractant protein-1(MCP-1).Methods The clinical data of 80 patients with CRF with poor prognosis after hemodialysis treated in our hospital from January 2016 to August 2020 were retrospectively analyzed,Serum VEGF and MCP-1 levels were observed in patients with poor prognosis and patients with good prognosis before hemodialysis treatment,and analyze the correlation between the levels of serum VEGF and MCP-1 and the prognosis of CRF patients after hemodialysis treatment.Results The serum levels of VEGF and MCP-1 in patients with poor prognosis were higher than those in patients with good prognosis,and the difference was statistically significant(P<0.05).Logistic regression analysis showed that high levels of serum VEGF and MCP-1 may be the influencing factors for poor prognosis of hemodialysis patients with CRF(OR>1,P<0.05).Conclusion The levels of serum VEGF and MCP-1 are closely related to the prognosis of CRF patients after hemodialysis,the higher the levels of serum VEGF and MCP-1,the higher the risk of poor prognosis of CRF patients after hemodialysis.