双歧杆菌对老年胃食管反流病长期质子泵抑制剂干预患者胃肠激素水平及肠道菌群的影响

Effect of Bifidobacterium on gastrointestinal hormone level and intestinal flora in elderly patients with gastroesophageal reflux disease after long-term proton pump inhibitor intervention

目的探讨双歧杆菌对老年胃食管反流病长期质子泵抑制剂(PPIs)干预患者胃肠激素水平及肠道菌群的影响。方法选取2018年12月至2020年12月于本院收治的120例长期采取PPIs干预的老年胃食管反流病患者为研究对象,按照随机数表法分为观察组与对照组,每组60例。观察组采用双歧杆菌联合PPIs治疗,对照组采用PPIs治疗。比较两组胃肠激素[生长抑素(SS)、血浆胃动素(MTL)、P物质(SP)]水平、肠道菌群、不良反应发生率。结果治疗后,观察组SP、MTL水平均高于对照组,SS水平低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组大肠埃希菌、葡萄球菌低于对照组,乳酸杆菌、双歧杆菌均高于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率(8.33%)低于对照组(21.67%),差异有统计学意义(P<0.05)。结论双歧杆菌可调节老年胃食管反流病长期PPIs干预患者的胃肠激素水平,改善肠道菌群紊乱情况,具有重要临床价值。

Objective To investigate the effect of Bifidobacterium on gastrointestinal hormone level and intestinal flora in elderly patients with gastroesophageal reflux disease(GERD)after long-term proton pump inhibitors(PPIs)intervention.Methods 120 elderly patients with gastroesophageal reflux disease who were treated in our hospital for a long time were selected from December 2018 to December 2020 as the research subjects,and randomly divided into observation group and control group,with 60 cases in each group.The observation group was treated with Bifidobacterium combined with PPIs,while the control group was treated with PPIs,the gastrointestinal hormones(somatostatin[SS],plasma motilin[MTL]and substance P[SP])level,intestinal flora and the incidence of adverse reactions were compared between the two groups.Results After treatment,the levels of SP and MTL in the observation group were higher than those in the control group,while the level of SS was lower than that in the control group,the differences were statistically significant(P<0.05).After treatment,Escherichia coli and Staphylococcus in the observation group were lower than those in the control group,while Lactobacillus and Bifidobacterium were higher than those in the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in observation group(8.33%)was lower than that in control group(21.67%),and the difference was statistically significant(P<0.05).Conclusion Bifidobacterium has important clinical value in regulating the level of gastrointestinal hormones and improving the disorder of intestinal flora in elderly patients with gastroesophageal reflux disease after long-term PPIs intervention.