地屈黄体酮治疗排卵障碍性异常子宫出血的临床疗效及对患者子宫内膜厚度和血红蛋白水平的影响

Clinical effect of dydroprogesterone in the treatment of abnormal uterine bleeding with ovulation disorder and its effect on endometrial thickness and hemoglobin level

目的探讨地屈黄体酮治疗排卵障碍性异常子宫出血的临床疗效及对患者子宫内膜厚度和血红蛋白水平的影响。方法选取2018年12月至2020年11月于本院治疗的110例排卵障碍性异常子宫出血患者作为研究对象,采取随机数字表法分为两组,每组55例。对照组采取米非司酮治疗,观察组采取地屈黄体酮治疗。比较两组临床疗效、月经量、血红蛋白(Hb)、子宫内膜厚度及不良反应。结果观察组治疗总有效率为94.55%,高于对照组的78.18%,差异有统计学意义(P<0.05);观察组用药期间不良反应发生率为3.64%,低于对照组的14.55%,差异有统计学意义(P<0.05);治疗后,两组子宫内膜厚度均薄于治疗前,月经量均少于治疗前,Hb水平高于治疗前,且观察组子宫内膜厚度薄于对照组,月经量少于对照组,Hb水平高于对照组,差异有统计学意义(P<0.05)。结论地屈黄体酮治疗排卵障碍性异常子宫出血疗效显著,可改善子宫内膜厚度,提高Hb水平,减少月经量,且安全性较高,值得临床推广应用。

Objective To explore the clinical effect of dydroprogesterone in the treatment of abnormal uterine bleeding with ovulation disorder and its effect on endometrial thickness and hemoglobin level.Methods 110 patients with abnormal uterine bleeding with ovulation disorder who were treated in our hospital from December 2018 to November 2020 were selected as the research subjects,and they were randomly divided into two groups according to random number table method,with 55 cases in each group.The control group received mifepristone treatment,while the observation group received dexamethasone treatment,the clinical efficacy,menstrual volume,hemoglobin(Hb),endometrial thickness and adverse reactions were compared between the two groups.Results The total effective rate in the observation group was 94.55%,which was higher than 78.18%in the control group,the difference was statistically significant(P<0.05);the adverse reaction rate during the medication period in the observation group was 3.64%,which was lower than 14.55%in the control group,the difference was statistically significant(P<0.05);after treatment,the thickness of the endometrium of two groups were thinner than before treatment,the menstrual volume were less than before treatment,and the Hb level were higher than before treatment,and the thickness of the endometrium in the observation group was thinner than that in the control group,the menstrual volume was less than that in the control group,and the Hb level was higher than that in the control group,the differences were statistically significant(P<0.05).Conclusion Diethylprogesterone has significant therapeutic effect on abnormal uterine bleeding with ovulation disorder,which can improve endometrial thickness,increase Hb levels,reduce menstrual flow,and has high safety,it is worthy of clinical promotion and application.