肿瘤坏死因子-α、c-Jun氨基末端激酶和黏蛋白2在肠屏障功能障碍中的研究进展

Research progress of tumor necrosis factorα/c-Jun N-terminal kinase/mucin 2 in intestinal barrier dysfunction

肠道黏液屏障和机械屏障均是最重要的天然屏障,前者为第一道防御屏障,可将肠腔内病原菌与上皮细胞隔开,防止一些致病物质透过肠屏障进到人体循环系统。研究表明,体内出现炎症会影响黏液层中关键蛋白黏蛋白2的含量进而改变黏液屏障的通透性,促进病原微生物的移位;而肿瘤坏死因子-α和c-Jun氨基末端激酶信号通路均已报道与炎症的发生发展密切相关。因此该文综述了肿瘤坏死因子-α、c-Jun氨基末端激酶通路以及黏蛋白2与肠屏障功能障碍之间的联系,以期为探索肠屏障功能相关研究提供新思路与方向。

The gut mucus barrier and mechanical barrier are the most important natural barriers,the former is the first defense barrier,which separates pathogenic bacteria in intestinal lumen from the epithelial cells,and prevents them passing through the intestinal barrier into the human circulation system.Studies have shown that inflammation in the body affects the content of mucin 2,a key protein in the mucus layer,thereby changing the permeability of the mucus barrier and promoting the translocation of pathogenic microorganisms.Both tumor necrosis factor-αand c-jun Nterminal kinase signaling pathways have been reported to be closely related to the occurrence and development of inflammation.Therefore,this article reviews the relationship between tumor necrosis factor-α,c-jun N-terminal kinase signaling pathway and mucin 2 and intestinal barrier dysfunction,in order to provide new ideas and directions for exploring the related research of intestinal barrier function.