临床细菌生物膜感染新型治疗方案研究进展

Research progress of new treatment options for clinical bacterial biofilm infection

细菌生物膜至少与80%的人类细菌感染相关。临床治疗生物膜感染依然很困难,为此有许多生物膜感染新型治疗方案在研究,如益生菌及其衍生物、群体感应抑制剂、抗菌肽、噬菌体疗法、有机酸、光学疗法、植物提取物等。但这些方案绝大多数还不成熟,开发新的抗生物膜研究方向也很重要。

Bacterial biofilms are associated with at least 80%of human bacterial infections.The clinical treatment of biofilm infection is still arduous,and therefore many new treatment options are under study,such as probiotics and their derivatives,quorum sensing inhibitors,antimicrobial peptides,phage therapy,organic acids,light therapy,and plant extracts.However,most of these schemes are not mature,and it is important to develop new research directions of antibiofilms.