奥氮平用于精神分裂症维持性治疗中的作用评价

Evaluation of evaluation of olanzapine in the maintenance treatment of schizophrenia

目的探讨奥氮平用于精神分裂症维持性治疗中的作用。方法选取2018年10月至2019年10月本院收治的108例精神分裂症患者作为研究对象,按照随机摸球法分为常规组与实验组,每组54例。两组均实施无抽搐电休克疗法,常规组给予氯氮平维持性治疗,实验组给予奥氮平维持性治疗。比较两组临床疗效、临床症状、认知功能与社会功能、不良反应发生情况。结果实验组治疗总有效率为96.30%,高于常规组的81.84%,差异有统计学意义(P<0.05)。治疗后,实验组阳性症状、阴性症状、一般精神症状评分均低于常规组,差异有统计学意义(P<0.05)。治疗后,实验组简易智力量表(MMSE)评分高于常规组,社会功能缺陷筛选量表(SDSS)评分低于常规组,差异有统计学意义(P<0.05)。实验组不良反应发生率低于常规组,差异有统计学意义(P<0.05)。结论奥氯平治疗精神分裂症效果显著,可减轻患者临床症状,改善其认知功能与社会功能,且不良反应少。

Objective To explore evaluation of olanzapine in the maintenance treatment of schizophrenia.Methods 108 patients with schizo-phrenic admitted to our hospital from October 2018 to October 2019 were selected as the research subjects,and they were divided into the conven-tional group and the experimental group according to random ball-touching method,with 54 cases in each group.Both groups were treated with non-convulsive electroconvulsive therapy,the conventional group was given maintenance treatment with clozapine,and the experimental group was given maintenance treatment with olanzapine.The clinical efficacy,clinical symptoms,cognitive and social functions,and the occurrence of adverse reac-tions were compared between the two groups.Results The total effective rate of treatment in the experimental group was 96.30%,which was higher than 81.84%in the conventional group,and the difference was statistically significant(P<0.05).After treatment,the scores of positive symptoms,negative symptoms,and general psychiatric symptoms in the experimental group were lower than those in the conventional group,and the differenc-es were statistically significant(P<0.05).After treatment,the score of mini-mental state examination(MMSE)in the experimental group was higher than that in the conventional group,and the score of social disability screening schedule(SDSS)was lower than that in the conventional group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was lower than that in the con-ventional group,and the difference was statistically significant(P<0.05).Conclusion Oclozapine in the treatment of schizophrenia has significant effect,which can reduce the clinical symptoms,improve the cognitive and social functions of patients,and has few adverse reactions.