炎症因子在严重腹腔感染中的表达水平及其临床意义

Expression and clinical significance of inflammatory factors in severe abdominal infection

目的分析炎症因子在严重腹腔感染中的表达水平及其临床意义。方法选取2018年1月至2020年1月本院收治的80例腹腔感染患者作为研究对象,按照急性生理和慢性健康评分(APACHEⅡ)分为严重感染组(APACHEⅡ评分>20分)与普通感染组(APACHEⅡ评分≤20分),每组40例;另选取同期本院无腹腔感染的40名健康体检者作为对照组,比较3组入院时或体检时血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、超敏C-反应蛋白(hs-CRP)、白细胞计数(WBC)及降钙素原(PCT)水平,分析TNF-α、IL-6、hs-CRP、WBC和PCT与腹腔感染严重程度的关系。结果严重感染组与普通感染组治疗前血清TNF-α、IL-6、hs-CRP、WBC和PCT水平均高于对照组,且严重感染组高于普通感染组,差异有统计学意义(P<0.05);治疗后,严重感染组与普通感染组血清TNF-α、IL-6、hs-CRP、WBC和PCT水平均明显低于治疗前,但严重感染组仍高于普通感染组,差异有统计学意义(P<0.05)。Spearman相关性分析结果显示,血清TNF-α、IL-6、hs-CRP、WBC和PCT均与腹腔感染严重程度呈正相关(r>0,P<0.05)。结论血清TNF-α、IL-6和hs-CRP、WBC和PCT在严重腹腔感染中表达异常升高,且与腹腔感染的严重程度呈正相关,对于腹腔感染严重程度的界定起到一定的辅助作用,且对疾病的诊治与预后评估具有一定的意义。

Objective To analyze the expression and clinical significance of inflammatory factors in severe abdominal infection.Methods 80 patients with abdominal infection in our hospital from January 2018 to January 2020 were selected as the research subjects,and they were divided in-to severe infection group(acute physiology,age and chronic health evaluationⅡ[APACHEⅡ]score>20 scores)and common abdominal infection group(APACHEⅡscore≤20 scores)according to APACHEⅡscore,with 40 cases in each group.Another 40 healthy people without abdominal in-fection in our hospital during the same period were selected as the control group,and the serum levels of tumor necrosis factor-α(TNF-α),interleu-kin-6(IL-6),hypersensitive C-reactive protein(hs-CRP),white blood cell count(WBC)and procalcitonin(PCT)at admission or physical examina-tion were compared among the three groups,and the relationship between the TNF-α,IL-6,hs-CRP,WBC and PCT and the severity of abdominal in-fection were analyzed.Results The serum levels of TNF-α,IL-6,hs-CRP,WBC and PCT in severe infection group and common abdominal infection group before treatment were higher than those in the control group,and severe infection group was higher than those in common abdominal infection group,the differences were statistically significant(P<0.05);after treatment,the serum levels of TNF-α,IL-6,hs-CRP,WBC,PCT in the severe infec-tion group and the common abdominal infection group were significantly lower than before treatment,but the severe infection group was still higher than those in common abdominal infection group,the difference was statistically significant(P<0.05).Spearman correlation analysis showed that se-rum TNF-α,IL-6,hs-CRP,WBC,PCT were positively correlated with the severity of abdominal infection(r>0,P<0.05).Conclusion Serum ex-pression of TNF-α,IL-6,hs-CRP,WBC and PCT were abnormally elevated in severe abdominal infection,and were positively correlation with the se-verity of abdominal infection,which plays certain auxiliary role in the definition of the severity of abdominal infection,and has certain significance for the diagnosis,treatment and prognosis evaluation of the disease.