美托洛尔联合胺碘酮治疗房颤的临床效果

Clinical effect of metoprolol combined with amiodarone in atrial fibrillation

目的探讨美托洛尔联合胺碘酮治疗房颤的临床效果。方法选取2019年3月至2020年7月本院收治的100例房颤患者作为研究对象,随机分为对照组与观察组,每组50例。对照组单一应用美托洛尔治疗,观察组采用美托洛尔联合胺碘酮治疗,比较两组临床疗效、心功能指标、膀抑素C、C反应蛋白、内皮素-1水平及不良反应发生情况。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。用药前,两组左心室射血分数、左心室舒张末期容积、心排血量、左心室收缩末期容积比较差异无统计学意义;用药后,两组左心室射血分数高于用药前,左心室舒张末期容积、心排血量均大于用药前,左心室收缩末期容积小于用药前,且观察组左心室射血分数高于对照组,左心室舒张末期容积、心排血量大于对照组,左心室收缩末期容积小于对照组,差异有统计学意义(P<0.05)。用药前,两组膀抑素C、C反应蛋白、内皮素-1水平比较差异无统计学意义;用药后,两组膀抑素C、C反应蛋白、内皮素-1水平均低于用药前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组用药不良反应发生率比较差异无统计学意义。结论美托洛尔联合胺碘酮治疗房颤效果显著,可显著改善患者心功能,安全性较高,值得临床推广应用。

Objective To investigate the clinical effect of metoprolol combined with amiodarone in atrial fibrillation.Methods The 100 atrial fibrillation patients admitted to our hospital from March 2019 to July 2020 were selected as the study subjects,and they were randomly divided into the control group and the observation group,with 50 cases in each group.The control group treated with metoprolol alone,and the observation group treated with metoprolol combined with amiodarone,the clinical efficacy,cardiac function indexes,the levels of blastatin C,C-reactive protein,endothelin-1 and the occurrence of adverse reactions were compared between the two groups.Results The total response rate in the observation group was higher than the control group,and the difference was statistically significant(P<0.05).Before medication,there were no significant differences in left ventricular ejection fraction,left ventricular end-diastolic volume,cardiac output and left ventricular end-systolic volume between the two groups.After medication,left ventricular ejection fraction was higher than before medication,left ventricular end-diastolic volume and cardiac output were greater than before medication,left ventricular end-systolic volume was smaller than before medication,and left ventricular ejection fraction in observation group was higher than control group,left ventricular end-diastolic volume and cardiac output was greater than control group,and left ventricular end-systolic volume was smaller than control group,and the differences were statistically significant(P<0.05).Before medication,there was no significant difference in the levels of blastatin C,C-reactive protein and endothelin-1 between the two groups;after administration,the levels of blastatin C,C-reactive protein and endothelin-1 of two groups were lower than those before medication,and the observation group was lower than the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse drug reactions between the two groups.Conclusion Metoprolol combined with amiodarone has remarkable results in the treatment of atrial fibrillation,which can significantly improve the cardiac function of patients,and is worthy of clinical promotion and application.