复方脑肽节苷脂联合多奈哌齐治疗老年血管性痴呆症的临床疗效

Clinical efficacy of compound brain peptide gangliosides combined with donepezil in the treatment of elderly vascular dementia

目的探讨复方脑肽节苷脂联合多奈哌齐治疗老年血管性痴呆症的临床疗效。方法选取2019年5月至2021年5月本院收治的96例老年血管性痴呆患者作为研究对象,采用随机方式分为研究组与对照组,每组48例。对照组采用多奈哌齐治疗,研究组采用复方脑肽节苷脂联合多奈哌齐,比较两组临床疗效、日常生活活动能力(ADL)评分、简易智力状态检查量表(MMSE)评分、健康调查简表(SF-36)评分、阿尔茨海默病相关的神经丝蛋白(AD7C-NTP)水平、不良反应情况。结果研究组治疗总有效率(95.83%)高于对照组(83.33%),差异有统计学意义(P<0.05);治疗后,两组ADL、MMSE评分高于治疗前,AD7c-NTP水平低于治疗前,且研究组ADL、MMSE评分均高于对照组,AD7c-NTP水平低于对照组,差异有统计学意义(P<0.05);治疗后,两组生理职能、社会职能、心理健康、情感交流评分均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为6.25%,略低于对照组的14.59%,但差异无统计学意义。结论复方脑肽节苷脂联合多奈哌齐治疗老年血管性痴呆疗效显著,可改善患者智能功能障碍,提高生活能力,具有临床推广应用价值。

Objective To explore the clinical efficacy of compound brain peptide gangliosides combined with donepezil in the treatment of elderly vascular dementia.Methods 96 elderly patients vascular dementia admitted to our hospital from May 2019 to May 2021 were selected as research subjects,and they were randomly divided into the study group and the control group,with 48 cases in each group.The control group was treated with donepezil,the study group was treated with compound brain peptide gangliosides combined with donepezil,the clinical efficacy and activity of daily living(ADL)score,Mini mental State Examination(MMSE)score,the MOS item short from healthsurvey(SF-36)score,Alzheimer's disease-associated neurofilament proteins(AD7c-NTP)level and adverse reactions were copared between the two groups.Results The effective rate of the study group(95.83%)was higher than that of the control group(83.33%),the difference was statistically significant(P<0.05).After treatment,the ADL and MMSE scores of two groups were higher than those before treatment,and the AD7c-NTP levels was lower than that before treatment,and the ADL and MMSE scores in the study group were higher than those in the control group,and the AD7c-NTP levels was lower than that in the control group,the differences were statistically significant(P<0.05);after treatment,the scores of physiological function,social function,mental health and emotional communication in two groups were higher than before treatment,and the study group was higher than the control group,the difference was statistically significant(P<0.05);the incidence of adverse reactions was 6.25%in the study group,which was slightly lower than 14.59%in the control group,but the difference was not statistically significant.Conclusion Compound brain peptide ganglioside combined with donepezil has a good therapeutic effect on elderly vascular dementia,can improve patients'intellectual dysfunction,improve their ability to live,and has clinical promotion and application value.