小剂量抗精神病药联合心理疗法治疗躯体化障碍的临床疗效

Clinical effect of small dose antipsychotics combined with psychotherapy in the treatment of somatization disorder

目的探究小剂量抗精神病药联合心理疗法治疗躯体化障碍的临床疗效。方法选取2019年1月至2020年10月本院收治的60例躯体化障碍患者作为研究对象,随机分为单一组和联合组,各30例。单一组采用小剂量抗精神病药治疗,联合组在单一组基础上联合心理疗法治疗,比较两组汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD)评分、临床疗效、生命质量评分及不良反应发生率。结果治疗前,两组HAMD、HAMA评分比较差异无统计学意义;治疗后,两组HAMD、HAMA评分均低于治疗前,且联合组低于单一组,差异有统计学意义(P<0.05)。联合组治疗总有效率为96.67%,高于单一组的60.00%,差异有统计学意义(P<0.05)。联合组物质、社会、心理、日常生活评分均高于单一组,差异有统计学意义(P<0.05)。联合组不良反应发生率为10.00%,低于单一组的33.33%,差异有统计学意义(P<0.05)。结论小剂量抗精神病药联合心理疗法治疗躯体化障碍的疗效显著,可明显改善患者抑郁、焦虑症状,且不良反应少,治疗安全性较高,还可提高患者生命质量,值得临床推广应用。

Objective To explore the clinical effect of small dose antipsychotics combined with psychotherapy in the treatment of somatization disorder.Methods A total of 60 patients with somatization disorder admitted to our hospital from January 2019 to October 2020 were selected as the research subjects,and they were randomly divided into single group and combined group,with 30 cases in each group.The single group was treated with small dose antipsychotic,and the combined group was treated with psychotherapy on the basis of the single group,the Hamilton anxiety scale(HAMA)score,Hamilton depression scale(HAMD)score,clinical efficacy,quality of life score and incidence of adverse reactions were compared between the two groups.Results Before treatment,there was no significant difference in HAMD and HAMA scores between the two groups;after treatment,HAMD and HAMA scores of the two groups were lower than before treatment,and the combined group was lower than the single group,and the differences were statistically significant(P<0.05).The total effective rate of the combined group was 96.67%,which was higher than 60.00%of the single group,and the difference was statistically significant(P<0.05).The scores of material,social,psychological and daily life in combined group were higher than those in the single group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in combined group was 10.00%,which was lower than 33.33%in single group,and the difference was statistically significant(P<0.05).Conclusion Small dose antipsychotics combined with psychotherapy is effective in the treatment of somatization disorder,which can significantly improve the symptoms of depression and anxiety in patients,with less adverse reactions,high safety,and can also improve the quality of life of patients,it is worthy of clinical application.