布地奈德福莫特罗吸入粉雾剂联合无创呼吸机治疗慢性阻塞性肺疾病的临床疗效及安全性

Clinical efficacy and safety of budesonide formoterol inhalation powder inhalation combined with noninvasive ventilator in the treatment of chronic obstructive pulmonary disease

目的探究布地奈德福莫特罗吸入粉雾剂联合无创呼吸机治疗慢性阻塞性肺疾病的临床疗效及安全性。方法选取2020年3月至2021年4月于本院住院治疗的100例慢性阻塞性肺疾病患者作为研究对象,根据治疗方案不同分为常规组与实验组,每组50例。常规组接受常规干预,实验组接受布地奈德福莫特罗吸入粉雾剂联合无创呼吸机治疗,比较两组临床疗效、不良反应发生率、肺功能指标、血气指标、生命质量评分。结果实验组治疗总有效率为98.00%,高于常规组的86.00%,差异有统计学意义(P<0.05)。实验组不良反应发生率为2.00%,低于常规组的14.00%,差异有统计学意义(P<0.05)。干预前,两组用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))、FEV_(1)/FVC比较差异无统计学意义;干预后,两组FVC、FEV_(1)、FEV_(1)/FVC均高于干预前,且实验组高于常规组,差异有统计学意义(P<0.05)。干预前,两组动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))比较差异无统计学意义;干预后,两组PaO_(2)均高于干预前,PaCO_(2)均低于干预前,且实验组PaO_(2)高于常规组,PaCO_(2)低于常规组,差异有统计学意义(P<0.05)。实验组躯体功能、心理情绪、社会能力、自我效能评分均高于常规组,差异有统计学意义(P<0.05)。结论布地奈德福莫特罗吸入粉雾剂联合无创呼吸机治疗慢性阻塞性肺疾病疗效显著,可有效改善患者肺功能与血气指标,提高其生命质量,值得临床推广应用。

Objective To investigate the clinical efficacy and safety of budesonide formoterol inhalation powder inhalation combined with noninvasive ventilator in the treatment of chronic obstructive pulmonary disease.Methods A total of 100 patients with chronic obstructive pulmonary disease hospitalized in our hospital from March 2020 to April 2021 were selected as the research subjects,and they were divided into conventional group and experimental group according to different treatment plans,with 50 cases in each group.The conventional group received conventional intervention,while the experimental group received budesonide formoterol inhalation powder inhalation combined with noninvasive ventilator treatment,the clinical efficacy,incidence of adverse reactions,pulmonary function indexes,blood gas indexes,and quality of life scores were compared between the two groups.Results The total effective rate of the experimental group was 98.00%,which was higher than 86.00%of the conventional group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was 2.00%,which was lower than 14.00%in the conventional group,and the difference was statistically significant(P<0.05).Before intervention,there was no significant difference in forced vital capacity(FVC),forced expiratory volume in one second(FEV_(1))and FEV_(1)/FVC between the two groups;after intervention,FVC,FEV_(1) and FEV_(1)/FVC of the two groups were higher than those before intervention,and the experimental group was higher than the conventional group,and the differences were statistically significant(P<0.05).Before intervention,there was no significant difference in partial pressure of oxygen(PaO_(2)),partial pressure of carbon dioxide(PaCO_(2))between the two groups;after intervention,PaO_(2) of the two groups was higher than that before intervention,PaCO_(2) was lower than that before intervention,and PaO_(2) in the experimental group was higher than that in the conventional group,PaCO_(2) was lower than that in the conventional group,the differences were statistically significant(P<0.05).The scores of physical function,psychological emotion,social ability and self-efficacy in the experimental group were higher than those in the conventional group,and the differences were statistically significant(P<0.05).Conclusion Budesonide formoterol inhalation powder inhalation combined with noninvasive ventilator is effective in the treatment of chronic obstructive pulmonary disease,it can effectively improve the pulmonary function and blood gas index of patients and improve their quality of life,it is worthy of clinical application.