结直肠癌术后辅助化疗序贯免疫治疗的应用效果

Application effect of adjuvant chemotherapy sequential immunotherapy after colorectal cancer surgery

目的分析结直肠癌术后辅助化疗序贯免疫治疗的应用效果。方法回顾性分析2018年12月至2020年12月本院收治的60例结直肠癌术后患者的临床资料,按照治疗方式不同分为实验组和对照组,各30例。对照组采取术后辅助化疗治疗,实验组采取术后辅助化疗序贯免疫治疗,比较两组免疫功能、毒副反应情况、生命质量。结果治疗前,两组CD8^(+)、CD4^(+)、B细胞、自然杀伤样T(NKT)细胞和自然杀伤(NK)细胞水平与CD4^(+)/CD8^(+)比较差异无统计学意义;治疗后,实验组CD8^(+)、B细胞、NKT细胞水平均低于对照组,CD4^(+)、NK细胞水平及CD4^(+)/CD8^(+)均高于对照组,差异有统计学意义(P<0.05)。实验组毒副反应发生率为16.67%,明显低于对照组的46.67%,差异有统计学意义(P<0.05)。实验组生理职能、生理功能、活力、精神健康、情感职能、社会功能、躯体疼痛、总体健康评分均高于对照组,差异有统计学意义(P<0.05)。结论结直肠癌术后辅助化疗序贯免疫治疗的效果理想,可明显改善患者免疫功能与生命质量,且基本不会引起毒副反应,值得临床推广应用。

Objective To analyze the effect of adjuvant chemotherapy sequential immunotherapy after colorectal cancer surgery.Methods The clinical data of 60 patients with colorectal cancer after surgery admitted to our hospital from December 2018 to December 2020 were retrospectively analyzed,they were divided into experimental group and control group according to different treatment methods,with 30 cases in each group.The control group was treated with postoperative adjuvant chemotherapy,and the experimental group was treated with postoperative adjuvant chemotherapy sequential immunotherapy,the immune function,toxicity and quality of life were compared between the two groups.Results Before treatment,there was no significant difference in the levels of CD8^(+),CD4^(+),B cells,natural killer T(NKT)cells,natural killer(NK)cells and CD4^(+)/CD8^(+)between the two groups;after treatment,the levels of CD8^(+),B cells and NKT cells in the experimental group were lower than those in the control group,and the levels of CD4^(+),NK cells and CD4^(+)/CD8^(+)were higher than those in the control group,the differences were statistically significant(P<0.05).The incidence of toxic and side effects in the experimental group was 16.67%,which was significantly lower than 46.67%in the control group,and the difference was statistically significant(P<0.05).The scores of physiological function,physiological function,vitality,mental health,emotional function,social function,physical pain and overall health in the experimental group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The effect of adjuvant chemotherapy sequential immunotherapy after colorectal cancer surgery is ideal,which can significantly improve the immune function and quality of life of patients without causing toxic and side effects,it is worthy of clinical application.