尼麦角林辅助治疗老年急性脑梗死患者的效果及对患者神经功能的影响

Effect of nicergoline adjuvant therapy on elderly patients with acute cerebral infarction and its effect on neurological function

目的探究尼麦角林辅助治疗老年急性脑梗死患者的效果及对患者神经功能的影响。方法回顾性分析2020年5月至2021年8月本院收治的60例老年急性脑梗死患者的临床资料,根据治疗方式不同分为对照组与观察组,各30例。对照组采用血栓通静脉滴注治疗,观察组于对照组基础上采用尼麦角林注射液肌内注射辅助治疗,比较两组临床疗效、治疗前后神经功能及不良反应发生情况。结果观察组治疗总有效率(93.33%)高于对照组(70.00%),差异有统计学意义(P<0.05)。治疗前,两组简易精神状态评估量表(MMSE)、蒙特利尔认知评估量表(MoCA)、美国国立卫生研究院卒中量表(NIHSS)评分比较差异无统计学意义;治疗后,两组MMSE、MoCA评分均高于治疗前,NIHSS评分均低于治疗前,且观察组MMSE、MoCA评分均高于对照组,NIHSS评分低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论尼麦角林辅助治疗老年急性脑梗死效果显著,可进一步改善患者神经功能,增强治疗效果,安全性较高,值得临床推广应用。

Objective To explore the effect of nicergoline adjuvant therapy on elderly patients with acute cerebral infarction and its effect on neurological function.Methods The clinical data of 60 elderly patients with acute cerebral infarction admitted to our hospital from May 2020 to August 2021 were retrospectively analyzed,and they were divided into control group and observation group according to different treatment methods,with 30 cases in each group.The control group was treated with Xueshuantong intravenous drip,and the observation group was treated with intramuscular injection of nicergoline injection on the basis of the control group,the clinical efficacy,neurological function before and after treatment and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group(93.33%)was higher than that in the control group(70.00%),and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in minimental state examination(MMSE),Montreal cognitive assessment(MoCA)and National Institute of Health stroke scale(NIHSS)scores between the two groups;after treatment,the MMSE and MoCA scores of the two groups were higher than those before treatment,and the NIHSS scores were lower than those before treatment,and the MMSE and MoCA scores in the observation group were higher than those in the control group,and the NIHSS score was lower than that in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Niergoline has significant effect in the treatment of acute cerebral infarction in the elderly,which can further improve the neurological function of patients,enhance the treatment effect,and has high safety,which is worthy of clinical promotion and application.