氨磺必利联合重复经颅磁刺激治疗精神分裂症的预后效果

Prognostic effect of sulfaapride combined with repeated transcranial magnetic stimulation in the treatment of schizophrenia

目的探究氨磺必利联合重复经颅磁刺激(rTMS)治疗精神分裂症的预后效果。方法选取2019年1—12月本院收治的95例精神分裂症患者作为研究对象,按照随机数字表法分为对照组(n=47)与观察组(n=48)。对照组接受氨磺必利治疗,观察组接受氨磺必利联合rTMS治疗,比较两组阳性和阴性症状量表(PANSS)评分、重复性成套神经心理状态测验(RBANS)评分、不良反应发生情况。结果治疗前,两组阳性症状、阴性症状、一般病理评分及总分比较差异无统计学意义;治疗后,两组阳性症状、阴性症状、一般病理评分及总分均低于治疗前(P<0.05),且观察组阴性症状评分、总分均低于对照组(P<0.05),两组阳性症状、一般病理评分比较差异无统计学意义。治疗前,两组言语功能、即刻记忆、延迟记忆、空间结构、注意力评分比较差异无统计学意义;治疗后,两组即刻记忆、延迟记忆、空间结构、注意力评分均高于治疗前,且观察组高于对照组(P<0.05),两组言语功能与治疗前比较差异无统计学意义,且组间比较差异无统计学意义。观察组不良反应发生率为21.28%,与对照组的17.02%比较差异无统计学意义。结论氨磺必利联合rTMS治疗精神分裂症效果显著,可明显控制患者阴性症状,有效改善患者神经心理状态,且治疗安全性较高,值得临床推广应用。

Objective To investigate the prognosis effect of sulfaapride combined with repeated transcranial magnetic stimulation(rTMS)in the treatment of schizophrenia.Methods 95 schizophrenic patients admitted to our hospital from January to December 2019 were selected as the research subjects,and they were divided into the control group(n=47)and the observation group(n=48)according to the random number table method.The control group was treated with sulfaapride,and the observation group was treated with sulfaapride combined with rTMS,the positive and negative syndrome scale(PANSS)scores,repeatable battery for the assessment of neuropsychological status(RBANS)scores,and adverse reactions were compared between the two groups.Results Before treatment,there was no significant difference in positive symptom score,negative symptom score,general pathological score and total score between the two groups;after treatment,the scores of positive symptom,negative symptom,general pathological and total score of the two groups were lower than those before treatment(P<0.05),and the negative symptom score and total score in the observation group were lower than those in the control group(P<0.05),there was no significant difference in positive symptom score and general pathological score between the two groups.Before treatment,there was no significant difference the scores of speech function,immediate memory,delayed memory,spatial structure and attention score between the two groups;after treatment,the scores of immediate memory,delayed memory,spatial structure and attention of the two groups were higher than those before treatment,and the observation group were higher than the control group(P<0.05),there was no significant difference in speech function between the two groups before and after treatment,and there was no significant difference between the two groups.The incidence of adverse reactions in the observation group was 21.28%,which was not significantly different from 17.02%in the control group.Conclusion The combination of sulfaapride and rTMS is effective in the treatment of schizophrenia,which can significantly control the negative symptoms of patients,effectively improve the neuropsychological status of patients,and has high treatment safety,and is worthy of clinical promotion and application.