高压氧联合重复经颅磁刺激治疗对脑梗死患者认知功能的改善情况

Improvement of cognitive function in patients with cerebral infarction by hyperbaric oxygen combined with repeated transcranial magnetic stimulation

目的探究高压氧(HBO)联合重复经颅磁刺激(rTMS)治疗对脑梗死患者认知功能的改善情况。方法选取2019年1月至2021年1月本院收治的92例脑梗死患者作为研究对象,按照随机数字表法分为两组,每组46例。两组均接受药物治疗+认知功能训练,在此基础上,对照组接受rTMS治疗,观察组在对照组基础上联合HBO治疗,比较两组蒙特利尔认知评估量表(MoCA)评分及P300检测结果。结果治疗前,两组视空间/执行、命名、注意力、语言、抽象能力、延迟记忆、定向力评分及总分比较差异无统计学意义。治疗后,观察组注意力、延迟记忆、定向力评分及总分均高于对照组,差异有统计学意义(P<0.05);两组视空间/执行、命名、语言、抽象能力评分比较差异无统计学意义。治疗前,两组潜伏期、波幅比较差异无统计学意义;治疗后,两组潜伏期均短于治疗前,波幅均大于治疗前,且观察组潜伏期均短于对照组,波幅均大于对照组,差异有统计学意义(P<0.05)。结论HBO联合rTMS治疗可明显改善脑梗死患者认知功能,值得临床推广应用。

Objective To explore the effect of cognitive function in patients with cerebral infarction by hyperbaric oxygen(HBO)combined with repeated transcranial magnetic stimulation(rTMS).Methods A total of 92 patients with cerebral infarction admitted to our hospital from January 2019 to January 2021 were selected as the research subjects,and they were divided into two groups according to the random number table method,with 46 cases in each group.Both groups received drug therapy+cognitive function training,on this basis,the control group received rTMS treatment,and the observation group received HBO treatment on the basis of the control group,the Montreal cognitive assessment(MoCA)score and P300 test results were compared between the two groups.Results Before treatment,there was no significant difference in visual space/execution,naming,attention,language,abstract ability,delayed memory,orientation score and total score between the two groups.After treatment,the attention,delayed memory,orientation score and total score in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05);there was no significant difference in visual space/execution,naming,language and abstract ability score between the two groups.Before treatment,there was no significant difference in latency and amplitude between the two groups;after treatment,the latency of the two groups was shorter than that before treatment,and the amplitude was greater than that before treatment,and the latency in the observation group was shorter than that in the control group,and the amplitude was greater than that in the control group,the differences were statistically significant(P<0.05).Conclusion HBO combined with rTMS can significantly improve the cognitive function of patients with cerebral infarction,which is worthy of clinical promotion and pplication.