间苯三酚联合低分子肝素钠保胎治疗对孕早期先兆流产患者性激素水平及不良母婴结局的影响

Effects of phloroglucinol combined with low molecular weight heparin sodium for fetal preservation therapy on sex hormones levels and adverse maternal-infant outcomes in patients with threatened abortion in early pregnancy

目的探究间苯三酚联合低分子肝素钠保胎治疗对孕早期先兆流产患者性激素水平及不良母婴结局的影响。方法选取2019年1月至2020年1月本院收治的60例孕早期先兆流产患者作为研究对象,按照随机数字表法分为对照组与观察组,各30例。对照组采用间苯三酚治疗,观察组在对照组基础上联合低分子肝素钠治疗,比较两组临床疗效、临床症状减轻时间、不良反应发生率、性激素水平及不良母婴结局发生率。结果观察组疗效分级优于对照组,治疗总有效率高于对照组,差异有统计学意义(P<0.05)。观察组阴道流血、腰痛和腹痛症状减轻时间均短于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。观察组不良母婴结局发生率低于对照组,差异有统计学意义(P<0.05)。治疗后,两组孕酮(P)、雌二醇(E_(2))、人绒毛膜促性腺激素(HCG)水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。结论间苯三酚联合低分子肝素钠保胎效果显著,能更快缓解临床症状,提高患者性激素水平,降低不良反应及不良母婴结局发生率,值得临床推广应用。

Objective To explore the effects of phloroglucinol combined with low molecular weight heparin sodium for fetal preservation therapy on sex hormones levels and maternal-infant outcomes in patients with threatened abortion in early pregnancy.Methods 60 patients with threatened abortion in early pregnancy admitted to our hospital from January 2019 to January 2020 were selected as the research subjects,and they were divided into the control group and the observation group according to random number table method,with 30 cases in each group.The control group was treated with phloroglucinol,and the observation group was treated with low molecular weight heparin sodium on the basis of the control group,the clinical efficacy,relief times of clinical symptom,incidence rates of adverse reactions,levels of sex hormones and incidence of adverse maternal-infant outcomes were compared between the two groups.Results The efficacy grading in the observation group was better than that in the control group,and the total effective rate in treatment was higher than that in the control group,and the difference was statistically significant(P<0.05).The relief times of vaginal bleeding,low back pain and abdominal pain in the observation group were shorter than that in the control group,and the difference was statistically significant(P<0.05).The incidence rates of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse maternal-infant outcomes in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of progesterone(P),estradiol(E2)and human chorionic gonadotropin(HCG)of the two groups were higher than those before treatment,and the observation group were higher than the control group,and the difference was statistically significant,and the difference was statistically significant(P<0.05).Conclusion Phloroglucinol combined with low molecular weight heparin sodium has significant effect on fetal preservation,can relieve the clinical symptoms faster,improve sex hormones levels in patients,and reduce the incidence rates of adverse reactions and adverse maternal-infant outcomes,is worthy of clinical promotion and application.