针刺放血疗法联合盐酸西替利嗪对慢性荨麻疹患者抗氧化指标及复发的影响

Effect of acupuncture bloodletting therapy combined with cetirizine hydrochloride on antioxidant indexes and recurrence in patients with chronic urticaria

目的探究针刺放血疗法联合盐酸西替利嗪对慢性荨麻疹患者抗氧化指标及复发的影响。方法选取2020年4月至2021年3月新余市中医院皮肤科收治的89例慢性荨麻疹患者作为研究对象,采用随机数字表法分为对照组(n=44)与治疗组(n=45)。对照组给予盐酸西替利嗪片治疗,治疗组在对照组基础上联合针刺放血疗法治疗,比较两组临床疗效、抗氧化指标、不良反应发生情况及复发情况。结果治疗组治疗总有效率为97.78%,高于对照组的70.46%,差异有统计学意义(P<0.05)。治疗后,两组血清维生素E(VitE)、金属硫蛋白(MT)、谷胱甘肽过氧化物酶(GSH-Px)水平均明显高于治疗前,血清丙二醛(MDA)、活性氧(ROS)水平均明显低于治疗前,且治疗组血清VitE、MT、GSH-Px水平均高于对照组,血清MDA、ROS水平均低于对照组,差异有统计学意义(P<0.05)。治疗组不良反应发生率为2.22%,对照组为6.82%,两组比较差异无统计学意义。随访6个月,治疗组复发率为4.44%,低于对照组的31.11%,差异有统计学意义(P<0.05)。结论针刺放血疗法联合盐酸西替利嗪治疗慢性荨麻疹较单一西药治疗疗效更佳,能提高患者机体抗氧化酶活性,增强自由基清除能力,降低复发率,且不良反应较少,值得临床推广应用。

Objective To explore the effect of acupuncture bloodletting therapy combined with cetirizine hydrochloride on antioxidant indexes and recurrence of patients with chronic urticaria.Method 89 patients with chronic urticaria admitted to the department of Dermatology in Xinyu Hospital of Traditional Chinese Medicine from April 2020 to March 2021 were selected as the research subjects,and they were divided into the con-trol group(n=44)and the treatment group(n=45)according to random number table method.The control group was treated with cetirizine hydrochlo-ride tablets,while the treatment group was treated with acupuncture bloodletting therapy on the basis of the control group,the clinical efficacy,anti-oxidant index,adverse reactions and recurrence were compared between the two groups.Results The total effective rate in the treatment group was 97.78%,which was higher than 70.46%in the control group,and the difference was statistically significant(P<0.05).After treatment,the serum lev-els of vitamin E(Vit E),metallothionein(MT)and glutathione peroxidase(GSH-Px)of the two groups were significantly higher than those before treatment,and the serum levels of malonaldehyde(MDA)and reactive oxygen species(ROS)were significantly lower than those before treatment,and the serum levels of Vit E,MT and GSH-Px in the treatment group were significantly higher than those in the control group,while the levels of MDA and ROS were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the treatment group was 2.22%,while that in the control group was 6.82%,there was no significant difference between the two groups.After 6 months of follow-up,the recurrence rate in the treatment group was 4.44%,which was lower than 31.11%in the control group,and the difference was statistically significant(P<0.05).Conclusion Acupuncture bloodletting therapy combined with cetirizine hydrochloride in the treat-ment of chronic urticaria has better efficacy than single western medicine,which can improve the activity of antioxidant enzymes,enhance the ability of free radical scavenging and reduce the recurrence rate,and has fewer adverse reactions,which is worthy of clinical promotion and application.