盐酸二甲双胍联合门冬胰岛素治疗妊娠期糖尿病的疗效及对患者不良母婴结局的影响

Effect of metformin hydrochloride combined with insulin aspartate on gestational diabetes mellitus and adverse maternal-infant outcomes of patients

目的盐酸二甲双胍联合门冬胰岛素联合治疗妊娠期糖尿病(GDM)的疗效及对患者不良母婴结局的影响。方法选取2018年12月至2021年2月经本院确诊的80例GDM患者作为研究对象,根据治疗方法不同分为实验组与对照组,每组40例。对照组给予门冬胰岛素治疗,实验组在对照组基础上联合二甲双胍治疗,比较两组临床指标及不良母婴结局。结果治疗前,两组稳态模型评估-胰岛素抵抗指数(HOMA-IR)和血清促代谢因子(Betatrophin)、白细胞介素-6(IL-6)、胰高血糖素样肽-1(GLP-1)、网膜素-1(omentin-1)水平比较差异无统计学意义;治疗后,两组HOMA-IR和血清Betatrophin、IL-6水平均低于治疗前,血清GLP-1、omentin-1水平均高于治疗前,且实验组HOMA-IR和血清Betatrophin、IL-6水平均低于对照组,血清GLP-1、omentin-1水平均高于对照组,差异有统计学意义(P<0.05)。实验组不良母婴结局发生率低于对照组,差异有统计学意义(P<0.05)。结论二甲双胍联合门冬胰岛素治疗GDM效果较为理想,可改善患者临床症状及不良母婴结局。

Objective To effect of metformin hydrochloride combined with insulin aspartate on gestational diabetes mellitus(GDM)and adverse maternal-infant outcomes of patients.Methods A total of 80 GDM patients diagnosed in our hospital from December 2018 to February 2021 were selected as the research subjects,and they were divided into experimental group and control group according to different treatment methods,with 40 cases in each group.The control group was treated with insulin aspartate,and the experimental group was treated with metformin hydrochloride on the basis of the control group,the clinical indexes and adverse maternal and infant outcomes were compared between the two groups.Results Be-fore treatment,there was no significant difference in homeostasis model assessment for insulin resistance index(HOMA-IR)and serum Betatrophin,interleukin-6(IL-6),glucagon-like peptide-1(GLP-1)and omentin-1 between the two groups;after treatment,HOMA-IR,and serum Betatrophin and IL-6 levels in both groups were lower than before treatment,while serum GLP-1 and omentin-1 levels in both groups were higher than before treat-ment,and HOMA-IR,and serum Betatrophin and IL-6 levels in the experimental group were lower than those in the control group,while the serum GLP-1 and omentin-1 levels were higher than those in the control group,the difference was statistically significant(P<0.05).The incidence of ad-verse maternal and infant outcomes in the experimental group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Metformin hydrochloride combined with insulin aspartate in the treatment of GDM has an ideal effect,which can improve clinical symptoms and adverse maternal-infant outcomes.