快速现场细胞学评估在经皮肺穿刺活检术诊断肺癌中的应用

Rapid on-site evaluation of cytology in the diagnosis of lung cancer by percutaneous lung puncture biopsy

目的探讨快速现场细胞学评估(C-ROSE)在经皮肺穿刺活检术诊断肺癌中的临床价值。方法选取2019年1月至2020年12月南京医科大学附属无锡第二医院收治的60例肺占位患者作为研究对象,根据是否行C-ROSE分为C-ROSE组(n=31)和非C-ROSE组(n=29)。比较两组肺癌诊断率、穿刺并发症发生率,并分析C-ROSE与肺穿刺病理结果的一致性。结果C-ROSE组肺癌诊断率为90.3%,高于非C-ROSE组的69.0%,差异有统计学意义(P<0.05)。C-ROSE组出血、气胸发生率均明显低于非C-ROSE组,差异有统计学意义(P<0.05)。C-ROSE与肺穿刺病理结果Kappa值为0.783,具有高度一致性。结论C-ROSE应用于经皮肺穿刺活检诊断肺癌中临床价值较高,可提高肺癌诊断率,减少穿刺相关并发症发生率,值得临床推广应用。

Objective To investigate the clinical value of rapid on-site evaluation of cytology(C-ROSE)in the diagnosis of lung cancer by percu-taneous lung puncture biopsy.Methods 60 patients with lung space occupying admitted to Nanjing Medical University Affiliated Wuxi Second Hos-pital from January 2019 to December 2020 were selected as the research subjects,and they were randomly divided into C-ROSE group(n=31)and non-C-ROSE group(n=29)according to whether C-ROSE was performed or not.The diagnosis rate of lung cancer and the incidence of puncture complications were compared between the two groups,and the consistency of C-ROSE and pathological results of lung puncture biopsy was ana-lyzed.Results The diagnosis rate of lung cancer in the C-ROSE group was 90.3%,which was higher than 69.0%in the non-C-ROSE group,and the difference was statistically significant(P<0.05).The incidence of bleeding and pneumothorax in the C-ROSE group was significantly lower than those in the non-C-ROSE group,and the differences were statistically significant(P<0.05).The Kappa value of C-ROSE and pathological results of lung puncture biopsy was 0.783,which showed highly consistency.Conclusion Application of C-ROSE in the diagnosis of lung cancer by percuta-neous lung puncture biopsy has high clinical value,which can improve the diagnosis rate of lung cancer,and reduce the incidence of puncture-related complications,and is worthy of clinical promotion and application.