桑叶粉的润肠通便作用

Study on the Laxative Function of Mulberry Leaf Pow der

为了研究桑叶粉的润肠通便作用,文中对便秘模型小鼠给食低、中、高剂量桑叶粉(饲料中分别添加5%、10%、15%桑叶粉),通过测定小鼠采食量、体重增加、粪便数、粪便含水率、血清乙酰胆碱(acetylcholine, Ach)含量、胃动素(motilin, MTL)含量、一氧化氮(NO)含量,研究桑叶粉的润肠通便作用。结果表明,3个剂量组的粪便数和粪便含水率均显著高于便秘模型组(P<0.05),且3个剂量组的粪便数均达到或超过正常对照组的水平;低、中剂量桑叶粉组血清Ach和MTL含量显著高于便秘模型组(P<0.05),达到正常对照组水平,同时NO含量显著降低(P<0.05);添加桑叶粉对小鼠的采食量无影响,但会影响小鼠体重。本研究可为桑叶润肠通便功能产品的开发利用提供参考。

To study the laxative function of mulberry leaf powder,mice in constipation model were fed with low,medium and high doses of mulberry leaf powder(5%,10%and 15%mulberry leaf powder were added in the diet,respectively).The feed intake of mice,body weight gain,the number and water content of feces,acetylcholine(Ach),motilin(MTL)and nitric oxide(NO)levels of serum were measured.The results showed that the number and water content of feces in 3 dose treatment groups were significantly higher than those in the constipation model group(P<0.05),and the fecal number of the 3 dose groups all reached or exceeded the levels of normal control group.Low and medium dose treatment could significantly increase the content of Ach and MTL in serum compared with the constipation model group(P<0.05),reaching the level of normal control group,and reduce the content of NO at same time(P<0.05).In addition,feeding mulberry leaf powder didn’t affect the feed intake of mice,but affected their body weight.This study can provide a reference for the development and utilization of mulberry leaf as laxative products.